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Alpha-defensin

Probably contributes to the antimicrobial barrier function of the small bowel mucosa. Has antibacterial activity against attenuated mutants of S.typhimurium.

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Alpha-defensin 1

Also known as Alpha-defensin 1 (Cryptdin-1) (Defensin-related cryptdin peptide).
defensin, alpha 1: Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. Belongs to the alpha-defensin family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Biological Process: defense response to bacterium; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; response to drug

Alpha-defensin 10

Also known as Alpha-defensin 10 (Defensin-related cryptdin-10).
Probably contributes to the antimicrobial barrier function of the small bowel mucosa.

Alpha-defensin 11

Also known as Alpha-defensin 11 (Defensin-related cryptdin-11).
Probably contributes to the antimicrobial barrier function of the small bowel mucosa.

Alpha-defensin 13

Also known as Alpha-defensin 13 (Defensin-related cryptdin-13).
Probably contributes to the antimicrobial barrier function of the small bowel mucosa.

Alpha-defensin 14

Also known as Alpha-defensin 14 (Defensin-related cryptdin-14).
Probably contributes to the antimicrobial barrier function of the small bowel mucosa.

Alpha-defensin 15

Also known as Alpha-defensin 15 (Defensin-related cryptdin-15).
Probably contributes to the antimicrobial barrier function of the small bowel mucosa.

Alpha-defensin 16

Also known as Alpha-defensin 16 (Defensin-related cryptdin-16).
Probably contributes to the antimicrobial barrier function of the small bowel mucosa.

Alpha-defensin 17

Also known as Alpha-defensin 17 (Defensin-related cryptdin-17) (CRYP17).
Probably contributes to the antimicrobial barrier function of the small bowel mucosa.

Alpha-defensin 2

Also known as Alpha-defensin 2 (Cryptdin-1) (Defensin-related cryptdin-2).
defensin, alpha 2: Has broad-spectrum antimicrobial properties. Has antibacterial activity against the Gram-positive bacterium L.monocytogenes EGD and the Gram-negative bacteria E.coli ML-35p and avirulent S.typhimurium 7953, but not against the mouse- virulent S.typhimurium 14028S. Probably contributes to the antimicrobial barrier function of the small bowel mucosa. Belongs to the alpha-defensin family.

Cellular Component: extracellular space

Biological Process: defense response to bacterium; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; response to drug

Alpha-defensin 23

Also known as Alpha-defensin 23 (Defensin-related cryptdin-23).
defensin, alpha 23: May have microbicidal activities. Belongs to the alpha-defensin family.

Alpha-defensin 3

Also known as Alpha-defensin 3 (Defensin-related cryptdin-3).
defensin, alpha 27:

Cellular Component: extracellular space

Biological Process: defense response to bacterium; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; response to drug

Alpha-defensin 4

Also known as Alpha-defensin 4 (Defensin-related cryptdin-4).
DEFA4: Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production. Belongs to the alpha-defensin family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: phospholipid binding

Biological Process: antibacterial humoral response; defense response to bacterium; membrane disruption in another organism

Alpha-defensin 5

Also known as Alpha-defensin 5 (Defensin-related cryptdin-5).
Probably contributes to the antimicrobial barrier function of the small bowel mucosa.

Alpha-defensin 6/12

Also known as Alpha-defensin 6/12 (Defensin-related cryptdin-6/12) (Cryptdin-2).
Has broad-spectrum antimicrobial properties. Has antibacterial activity against the Gram-positive bacterium L.monocytogenes EGD and the Gram-negative bacteria E.coli ML-35p and avirulent S.typhimurium 7953, but not against the mouse-virulent S.typhimurium 14028S. Probably contributes to the antimicrobial barrier function of the small bowel mucosa.

Alpha-defensin 7

Also known as Alpha-defensin 7 (Defensin-related cryptdin-7).
Probably contributes to the antimicrobial barrier function of the small bowel mucosa.

Alpha-defensin 8

Also known as Alpha-defensin 8 (Defensin-related cryptdin-8).
Probably contributes to the antimicrobial barrier function of the small bowel mucosa.

Alpha-defensin 9

Also known as Alpha-defensin 9 (Defensin-related cryptdin-9).
Probably contributes to the antimicrobial barrier function of the small bowel mucosa.

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