Binds a variety of cellular promoters including fibrinogen, alpha-globin promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter (By similarity).
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Protein type: DNA-binding; Transcription factor
Cellular Component: nucleus; transcription factor complex
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter
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