• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Alpha-ketoglutarate-dependent dioxygenase

Putative dioxygenase that may repair alkylated DNA or RNA by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).

Below are the list of possible Alpha-ketoglutarate-dependent dioxygenase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Alpha-ketoglutarate-dependent dioxygenase abh1

Also known as Alpha-ketoglutarate-dependent dioxygenase abh1 (Alkylated DNA repair protein alkB homolog).
Putative dioxygenase that may repair alkylated DNA or RNA by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron ().

Alpha-ketoglutarate-dependent dioxygenase alkB

Also known as Alpha-ketoglutarate-dependent dioxygenase alkB (Alkylated DNA repair protein alkB homolog).
Putative dioxygenase that may repair alkylated DNA or RNA by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron ().

Alpha-ketoglutarate-dependent dioxygenase AlkB homolog

Also known as Alpha-ketoglutarate-dependent dioxygenase AlkB homolog (DNA oxidative demethylase AlkB).
Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents) ().

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

Also known as Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (Alkylated DNA repair protein alkB homolog 3).
Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron.

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

Also known as Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Alkylated DNA repair protein alkB homolog 4).
ALKBH4: Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.-

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: midbody

Molecular Function: actin binding; demethylase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; protein binding

Biological Process: actomyosin structure organization and biogenesis; protein amino acid demethylation

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7

Also known as Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (Alkylated DNA repair protein alkB homolog 7).
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity (). Involved in fatty acid metabolism ().

Alpha-ketoglutarate-dependent dioxygenase FTO

Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. May contribute to the regulation of the global metabolic rate, energy expenditure and energy homeostasis ().
Proteins Root Name Listing
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000