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Alpha-parvin

Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development.

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Alpha-parvin

Also known as Alpha-parvin (Actopaxin).
PARVA: Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Plays a role in ciliogenesis. Interacts with TGFB1I1. Interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Interacts with ARHGAP31. Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. Belongs to the parvin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Cellular Component: actin cytoskeleton; cell-cell adherens junction; cytoplasm; focal adhesion; lamellipodium; nucleus; protein complex

Molecular Function: actin binding; protein binding

Biological Process: actin cytoskeleton organization and biogenesis; cell adhesion; establishment and/or maintenance of cell polarity; heterotypic cell-cell adhesion; protein heterooligomerization; sprouting angiogenesis

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