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ALX homeobox protein

Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes .

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ALX homeobox protein 1

Also known as ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1).
Cart1: Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. Functions as a repressor with the prolactin promoter in vivo. May play a role in chondrocyte differentiation and may also influence cervix development. Defects in ALX1 are the cause of frontonasal dysplasia type 3 (FND3). The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline. Belongs to the paired homeobox family.

Protein type: DNA-binding

Cellular Component: Golgi apparatus; nucleoplasm; nucleus; transcription factor complex

Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity

Biological Process: anterior/posterior pattern formation; embryonic limb morphogenesis; embryonic skeletal morphogenesis; mesenchymal cell development; negative regulation of transcription from RNA polymerase II promoter; neural tube closure; palate development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent
Proteins Root Name Listing
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