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Aly/REF export factor

Export adapter involved in spliced and unspliced mRNA nuclear export. Binds mRNA which is transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway); enhances NXF1-NXT1 RNA-binding activity.

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Aly/REF export factor 2

Also known as Aly/REF export factor 2 (Alyref) (RNA and export factor-binding protein 2).
Refbp2: Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. Plays a role in mRNA processing and export. May function as scaffold that mediates interactions between proteins and/or RNA. Integral part of the THO/TREX complex that is recruited to transcribed genes and travels with the RNA polymerase during elongation. Is part of the exon junction complex that remains associated with spliced mRNA and plays an important role in mRNA export and nonsense-mediated RNA decay. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; RNA-binding

Molecular Function: RNA binding; single-stranded DNA binding

Biological Process: mRNA transport

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