Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel (By similarity).
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Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: Xp22.31-p22.1
Cellular Component: cell surface; proteinaceous extracellular matrix
Molecular Function: growth factor activity; hydroxyapatite binding; identical protein binding; protein binding; structural constituent of tooth enamel
Biological Process: biomineral formation; cell adhesion; cell proliferation; chondrocyte differentiation; epithelial to mesenchymal transition; ion homeostasis; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of collagen biosynthetic process; signal transduction
Disease: Amelogenesis Imperfecta, Type Ie