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Amelogenin

Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel (By similarity).

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Amelogenin

Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel ().

Amelogenin, X isoform

AMELX: Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. Defects in AMELX are the cause of amelogenesis imperfecta type 1E (AI1E). A X-linked defect of dental enamel formation. Teeth have only a thin layer of enamel with normal hardness. The thinness of the enamel makes the teeth appear small. Belongs to the amelogenin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xp22.31-p22.1

Cellular Component: cell surface; proteinaceous extracellular matrix

Molecular Function: growth factor activity; hydroxyapatite binding; identical protein binding; protein binding; structural constituent of tooth enamel

Biological Process: biomineral formation; cell adhesion; cell proliferation; chondrocyte differentiation; epithelial to mesenchymal transition; ion homeostasis; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of collagen biosynthetic process; signal transduction

Disease: Amelogenesis Imperfecta, Type Ie

Amelogenin, Y isoform

Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel ().

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