Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
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AREG: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts. Belongs to the amphiregulin family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component: cell surface; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; extracellular space
Molecular Function: epidermal growth factor receptor binding; growth factor activity; protein binding
Biological Process: cell proliferation; cell-cell signaling; COPII coating of Golgi vesicle; epidermal growth factor receptor signaling pathway; ER to Golgi vesicle-mediated transport; G-protein coupled receptor protein signaling pathway; positive regulation of cell proliferation; positive regulation of DNA replication