• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Amyloid beta A4 precursor protein-binding family

Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.

Below are the list of possible Amyloid beta A4 precursor protein-binding family products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the reer's specifications.

Amyloid beta A4 precursor protein-binding family A member 1

Also known as Amyloid beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1).
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]

Amyloid beta A4 precursor protein-binding family A member 2

Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP ().

Amyloid beta A4 precursor protein-binding family A member 3

Also known as Amyloid beta A4 precursor protein-binding family A member 3 (Adapter protein X11gamma) (Neuron-specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3).
APBA3: May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.

Protein type: Motility/polarity/chemotaxis

Cellular Component: perinuclear region of cytoplasm

Molecular Function: beta-amyloid binding; enzyme binding; enzyme inhibitor activity; protein binding

Biological Process: in utero embryonic development; negative regulation of catalytic activity; regulation of gene expression; synaptic transmission

Amyloid beta A4 precursor protein-binding family B member 1

Also known as Amyloid beta A4 precursor protein-binding family B member 1 (Protein Fe65).
Fe65: adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on Y142 (H2AXpY142) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as TIP60, probably explains its trancription activation activity.

Protein type: Adaptor/scaffold; Apoptosis; Transcription regulation

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: cytoplasm; growth cone; lamellipodium; nucleoplasm; nucleus; plasma membrane; synapse

Molecular Function: beta-amyloid binding; chromatin binding; histone binding; protein binding; transcription factor binding

Biological Process: cell cycle arrest; negative regulation of cell growth; negative regulation of thymidylate synthase biosynthetic process; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to DNA damage stimulus

Amyloid beta A4 precursor protein-binding family B member 2

APBB2: May modulate the internalization of beta-amyloid precursor protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Cellular Component: cytoplasm; nucleus

Molecular Function: beta-amyloid binding; protein binding; transcription factor binding

Biological Process: axon guidance; cell cycle arrest; extracellular matrix organization and biogenesis; negative regulation of apoptosis; negative regulation of cell growth; neuron migration; positive regulation of apoptosis; regulation of transcription, DNA-dependent

Amyloid beta A4 precursor protein-binding family B member 3

APBB3: May modulate the internalization of beta-amyloid precursor protein. 4 isoforms of the human protein are produced by alternative splicing.

Cellular Component: actin cytoskeleton; cytoplasm; nucleus

Molecular Function: beta-amyloid binding; transcription factor binding

Biological Process: negative regulation of apoptosis; regulation of transcription, DNA-dependent

Go back to Proteins Root Name Listing
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000