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Amyloid-like protein

May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.

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Amyloid-like protein 1

Also known as Amyloid-like protein 1 (APLP) (APLP-1).
APLP1: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. Belongs to the APP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: basement membrane; perinuclear region of cytoplasm; plasma membrane

Molecular Function: alpha-2A adrenergic receptor binding; alpha-2B adrenergic receptor binding; alpha-2C adrenergic receptor binding; identical protein binding; protein binding

Biological Process: G-protein signaling, adenylate cyclase inhibiting pathway; negative regulation of cAMP biosynthetic process; nervous system development; organ morphogenesis

Amyloid-like protein 2

Also known as Amyloid-like protein 2 (APLP-2) (APPH) (Amyloid protein homolog) (CDEI box-binding protein) (CDEBP).
APLP2: May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts. Belongs to the APP family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; DNA-binding; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q24

Cellular Component: membrane; nucleus; plasma membrane; platelet alpha granule membrane

Molecular Function: identical protein binding; protein binding

Biological Process: platelet degranulation

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