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Ancient ubiquitous protein

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.

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Ancient ubiquitous protein 1

AUP1: May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Belongs to the AUP1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Transferase

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: integral to endoplasmic reticulum membrane; membrane

Molecular Function: protein binding; ubiquitin binding

Biological Process: ER-associated protein catabolic process; retrograde protein transport, ER to cytosol

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