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Angiogenin

Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity).

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Angiogenin

Also known as Angiogenin (Angiogenin-1) (Ribonuclease 5) (RNase 5).
ANG: May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9). ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy. Belongs to the pancreatic ribonuclease family.

Protein type: Cell cycle regulation; EC 3.1.27.-; Extracellular matrix; Motility/polarity/chemotaxis; Nucleolus; RNA-binding; Ribonuclease; Secreted; Secreted, signal peptide

Cellular Component: angiogenin-PRI complex; basal lamina; cell soma; extracellular space; growth cone; nucleus

Molecular Function: actin binding; copper ion binding; endonuclease activity; heparin binding; peptide binding; protein homodimerization activity; receptor binding; ribonuclease activity; RNA binding

Biological Process: activation of phospholipase A2; activation of protein kinase B; angiogenesis; antibacterial humoral response; antifungal humoral response; cell migration; defense response to Gram-positive bacterium; diacylglycerol biosynthetic process; innate immune response; negative regulation of smooth muscle cell proliferation; phospholipase C activation; positive regulation of endothelial cell proliferation; positive regulation of phosphorylation; positive regulation of protein secretion; response to hormone stimulus; response to hypoxia; response to yeast; rRNA transcription

Angiogenin-1

Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonuclease activity.

Angiogenin-2

Binds tightly to placental ribonuclease inhibitor and has very low ribonuclease activity. Has potent angiogenic activity. Angiogenin induces vascularization of normal and malignant tissues. Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs.

Angiogenin-3

Also known as Angiogenin-3 (Angiogenin-related protein 2) (EF-5).
ANG3:

Protein type: EC 3.1.27.-

Molecular Function: endonuclease activity; ribonuclease activity

Angiogenin-4

ANG4: Has bactericidal activity against E.faecalis and L.monocytogenes, but not against L.innocua and E.coli. Promotes angiogenesis (in vitro). Has low ribonuclease activity (in vitro). Promotes proliferation of melanoma cells, but not of endothelial cells or fibroblasts (in vitro). Belongs to the pancreatic ribonuclease family.

Protein type: EC 3.1.27.-

Cellular Component: extracellular space; secretory granule

Molecular Function: endonuclease activity; ribonuclease activity

Biological Process: angiogenesis; antibacterial humoral response; defense response to bacterium; innate immune response; positive regulation of cell proliferation; RNA catabolic process

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