Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions (By similarity).
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Cellular Component: actin filament; cytoplasmic vesicle; endocytic vesicle; external side of plasma membrane; lamellipodium; ruffle; signalosome; tight junction
Molecular Function: angiostatin binding; protein binding; receptor activity
Biological Process: actin cytoskeleton organization and biogenesis; blood vessel endothelial cell migration; blood vessel morphogenesis; cell migration involved in gastrulation; chemotaxis; gastrulation with mouth forming second; in utero embryonic development; negative regulation of angiogenesis; positive regulation of embryonic development; regulation of cell migration; regulation of small GTPase mediated signal transduction; vasculogenesis