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Ankyrin repeat and LEM domain-containing protein

Endonuclease that probably plays a role in the DNA damage response and DNA repair.

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Ankyrin repeat and LEM domain-containing protein 1

Also known as Ankyrin repeat and LEM domain-containing protein 1 (Ankyrin repeat domain-containing protein 41) (LEM-domain containing protein 3).
ANKRD41: 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: cytoplasm; integral to nuclear inner membrane; nucleus

Molecular Function: chromatin DNA binding; endonuclease activity

Biological Process: determination of adult life span; DNA repair; erythrocyte maturation; negative regulation of mitotic recombination; nuclear membrane organization and biogenesis; protein export from nucleus; regulation of alpha-beta T cell differentiation; regulation of B cell differentiation; regulation of T cell differentiation in the thymus

Ankyrin repeat and LEM domain-containing protein 1 homolog

Also known as Ankyrin repeat and LEM domain-containing protein 1 homolog (LEM-domain containing protein 3).
Endonuclease which, in association with baf-1, plays an essential role during embryogenesis in the DNA repair response following DNA damage probably by ensuring proper chromosome segregation. Also required during postembryonic cell divisions after DNA damage caused by ionizing radiation to ensure normal cell proliferation.

Ankyrin repeat and LEM domain-containing protein 2

Also known as Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4).
ANKLE2: Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Belongs to the ANKLE2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: endoplasmic reticulum; integral to endoplasmic reticulum membrane; membrane

Molecular Function: protein phosphatase 2A binding

Biological Process: central nervous system development; mitotic nuclear envelope reassembly; negative regulation of apoptosis; negative regulation of phosphorylation; positive regulation of protein amino acid dephosphorylation

Ankyrin repeat and LEM domain-containing protein 2 homolog

Also known as Ankyrin repeat and LEM domain-containing protein 2 homolog (LEM domain-containing protein 4-like).
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of baf-1 during mitotic exit. Coordinates the control of baf-1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of baf-1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex.
Proteins Root Name Listing
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