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Ankyrin repeat domain-containing protein

May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.

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Ankyrin repeat domain-containing protein 11

ANKRD11: May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Defects in ANKRD11 are the cause of KBG syndrome (KBGS). A syndrome characterized by macrodontia of the upper central incisors, distinctive craniofacial findings, short stature, skeletal anomalies, and neurologic involvement that includes global developmental delay, seizures, and intellectual disability.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane

Biological Process: in utero embryonic development; multicellular organism growth; odontogenesis of dentine-containing teeth; skeletal morphogenesis; tissue homeostasis

Ankyrin repeat domain-containing protein 12

Also known as Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).
ANKRD12: May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 18p11.22

Cellular Component: cytoplasm; nucleoplasm

Ankyrin repeat domain-containing protein 13A

ANKRD13: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. Interacts (via the UIM 3 and 4 repeats) with EGFR (ubiquitinated); the interaction is direct, inhibited by ANKRD13A monoubiquitination and may regulate EGFR internalization

Protein type: Unknown function

Cellular Component: cytoplasm; plasma membrane

Ankyrin repeat domain-containing protein 13C

ANKRD13C: Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum

Cellular Component: endoplasmic reticulum; perinuclear region of cytoplasm

Molecular Function: receptor binding

Biological Process: protein retention in ER

Ankyrin repeat domain-containing protein 17

Also known as Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein).
ANKRD17: the earliest specific in situ marker of hepatic differentiation during embryogenesis, useful for characterization of inductive events involved in hepatic specification. Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease). Interacts with VP1 capsid protein of enterovirus 71 (EV71). Five alternatively processed human isoforms have been described.

Protein type: Cell development/differentiation

Cellular Component: chromatin; cytoplasm; membrane; nucleus

Molecular Function: chromatin binding

Biological Process: blood vessel maturation; defense response to bacterium; endoderm development; innate immune response; negative regulation of smooth muscle cell differentiation; positive regulation of cell cycle; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of DNA replication

Ankyrin repeat domain-containing protein 2

Also known as Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).
ANKRD2: May play an important role in skeletal muscle hypertrophy. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Contractile

Chromosomal Location of Human Ortholog: 10q23

Cellular Component: cytosol; euchromatin; I band; intracellular membrane-bound organelle; nucleus; sarcomere

Molecular Function: protein kinase B binding; titin binding

Biological Process: negative regulation of myoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter in response to oxidative stress

Ankyrin repeat domain-containing protein 20B

Also known as Ankyrin repeat domain-containing protein 20B (Ankyrin repeat domain-containing protein 20A pseudogene).
ANKRD20B: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2q11.1

Ankyrin repeat domain-containing protein 23

Also known as Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).
ANKRD23: May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression. 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: actin cytoskeleton; cytoplasm; I band; myofibril; nucleoplasm; nucleus

Molecular Function: titin binding

Biological Process: fatty acid metabolic process

Ankyrin repeat domain-containing protein 26

ANKRD26: a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 10p12.1

Cellular Component: centrosome

Disease: Thrombocytopenia 2

Ankyrin repeat domain-containing protein 27

May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics. May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7. Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38. Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1. Required for the colocalization of VAMP7 and Rab21, probably on TGN sites. Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29. Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes ().

Ankyrin repeat domain-containing protein 2A

Also known as Ankyrin repeat domain-containing protein 2A (AtAKR2).
Involved in targeting of chloroplast outer membrane proteins to the chloroplast. Double mutants of AKR2A and the highly homologous AKR2B have yellow leaves, significantly reduced chloroplast proteins, and no thylakoid membranes.

Ankyrin repeat domain-containing protein 30A

Also known as Ankyrin repeat domain-containing protein 30A (Serologically defined breast cancer antigen NY-BR-1).
ANKRD30A:

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 10p11.21

Ankyrin repeat domain-containing protein 30B

Also known as Ankyrin repeat domain-containing protein 30B (Serologically defined breast cancer antigen NY-BR-1.1).
ANKRD30B: 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 18p11.21

Ankyrin repeat domain-containing protein 36B

Also known as Ankyrin repeat domain-containing protein 36B (CLL-associated antigen KW-1).
Enzyme and pathway databasesBioCyc Collection of Pathway/Genome Databases<br/><a href='/database/5'>More..</a>BioCyciZFISH:ENSG00000180253-MONOMER.

Ankyrin repeat domain-containing protein 36C

Also known as Ankyrin repeat domain-containing protein 36C (Protein immuno-reactive with anti-PTH polyclonal antibodies).
ANKRD36C: Belongs to the ANKRD36 family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 2q11.1

Ankyrin repeat domain-containing protein 39

ANKRD39: a protein of unknown function. Contains four ankyrin(ANK) repeats. The ANK repeat is found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers.

Protein type: Unknown function

Ankyrin repeat domain-containing protein 50

ANKRD50: 2 isoforms of the human protein are produced by alternative splicing

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 4q28.1

Molecular Function: protein binding

Biological Process: intracellular protein transport

Ankyrin repeat domain-containing protein 6

Also known as Ankyrin repeat domain-containing protein 6 (Diversin).
ANKRD6: Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 6q15

Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleus

Biological Process: positive regulation of JNK cascade

Ankyrin repeat domain-containing protein A238L

Also known as Ankyrin repeat domain-containing protein A238L (p28).
Inhibits activation of the NF-kappa-B transcription factor by preventing binding of NF-kappa-B subunits RELA and NFKB3 to DNA. Inhibits also the activity of the calcium/calmodulin-regulated phosphatase calcineurin ().

Ankyrin repeat domain-containing protein CP77

Also known as Ankyrin repeat domain-containing protein CP77 (Host range protein 1).
Substrate-specific adapter of SKP1-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins. Prevents activation and subsequent nuclear localization of NF-kappa-B in infected cells, by targeting NF-kappa-B RELA subunit to the SCF E3 ligase complex.

Ankyrin repeat domain-containing protein M-T5

Also known as Ankyrin repeat domain-containing protein M-T5 (M-T5 protein) (M5).
Substrate-specific adapter of SKP1-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins including CDKN1B. Disappearance of host CDKN1B correlates with cell cycle progression through the G0/G1 checkpoint. Therefore, viruses in infected cells are protected from diverse innate host antiviral responses normally triggered by G0/G1 cell cycle arrest.

Ankyrin repeat domain-containing protein SOWAHB

Also known as Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B).
ANKRD56: Belongs to the SOWAH family.

Chromosomal Location of Human Ortholog: 4q21.1

Ankyrin repeat domain-containing protein SOWAHC

Also known as Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C).
ANKRD57: Belongs to the SOWAH family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 2q13
Proteins Root Name Listing
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