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Anoctamin

Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.

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Anoctamin-1

Also known as Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2).
ANO1: Acts as a calcium-activated chloride channel. Required for normal tracheal development. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: apical plasma membrane; plasma membrane

Molecular Function: calcium activated cation channel activity; chloride channel activity; intracellular calcium activated chloride channel activity; iodide transmembrane transporter activity; protein binding; voltage-gated chloride channel activity

Biological Process: cation transport; chloride transport; detection of temperature stimulus involved in sensory perception of pain; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); iodide transport

Anoctamin-10

Also known as Anoctamin-10 (Transmembrane protein 16K).
Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1 ().

Anoctamin-2

Also known as Anoctamin-2 (Transmembrane protein 16B).
ANO2: Acts as a calcium-activated chloride channel (CaCC), mostly in photoreceptors. May mediate olfactory amplification in olfactory sensory neurons (OSNs) and light perception amplification in retina. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Cellular Component: nucleoplasm; plasma membrane

Molecular Function: intracellular calcium activated chloride channel activity; phospholipid scramblase activity; protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: chloride transport

Anoctamin-3

Also known as Anoctamin-3 (Transmembrane protein 16C).
ANO3: May act as a calcium-activated chloride channel. Belongs to the anoctamin family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 11p14.2

Cellular Component: plasma membrane

Molecular Function: intracellular calcium activated chloride channel activity

Disease: Dystonia 24

Anoctamin-4

Also known as Anoctamin-4 (Transmembrane protein 16D).
ANO4: May act as a calcium-activated chloride channel. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 12q23.1

Cellular Component: intracellular; plasma membrane

Molecular Function: intracellular calcium activated chloride channel activity

Biological Process: chloride transport

Anoctamin-5

Also known as Anoctamin-5 (Gnathodiaphyseal dysplasia 1 protein homolog) (Transmembrane protein 16E).
ANO5: May act as a calcium-activated chloride channel. Defects in ANO5 are the cause of gnathodiaphyseal dysplasia (GDD); also known as osteogenesis imperfecta with unusual skeletal lesions or gnathodiaphyseal sclerosis. GDD is a rare skeletal syndrome characterized by bone fragility, sclerosis of tubular bones, and cemento-osseous lesions of the jawbone. Patients experience frequent bone fractures caused by trivial accidents in childhood; however the fractures heal normally without bone deformity. The jaw lesions replace the tooth-bearing segments of the maxilla and mandible with fibrous connective tissues, including various amounts of cementum-like calcified mass, sometimes causing facial deformities. Patients also have a propensity for jaw infection and often suffer from purulent osteomyelitis-like symptoms, such as swelling of and pus discharge from the gums, mobility of the teeth, insufficient healing after tooth extraction and exposure of the lesions into the oral cavity. Defects in ANO5 are the cause of limb-girdle muscular dystrophy type 2L (LGMD2L). It is an autosomal recessive degenerative myopathy characterized by proximal weakness, weakness of the hip and shoulder girdles and prominent asymmetrical quadriceps femoris and biceps brachii atrophy. Defects in ANO5 are the cause of miyoshi muscular dystrophy type 3 (MMD3). It is a late-onset muscular dystrophy characterized by distal muscle weakness of the lower limbs, calf muscle discomfort and weakness, quadriceps atrophy. Muscle weakness and atrophy may be asymmetric. Belongs to the anoctamin family.

Protein type: Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Cellular Component: intracellular; plasma membrane; vesicle

Molecular Function: intracellular calcium activated chloride channel activity; phospholipid scramblase activity

Biological Process: chloride transport

Anoctamin-6

Also known as Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F).
ANO6: May act as a calcium-activated chloride channel. It is essential for calcium-dependent exposure of phosphatidylserine on the surface of activated platelets, a process necessary to trigger the clotting system. Defects in ANO6 are the cause of Scott syndrome (SCTS). A mild bleeding disorder due to impaired surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with Ca(2+)-elevating agents. Belongs to the anoctamin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Cellular Component: cell surface; intracellular; membrane; plasma membrane

Molecular Function: calcium activated cation channel activity; intracellular calcium activated chloride channel activity; phospholipid scramblase activity; protein homodimerization activity; voltage-gated chloride channel activity; voltage-gated ion channel activity

Biological Process: activation of blood coagulation via clotting cascade; bleb formation; blood coagulation; cation transport; chloride transport; dendritic cell chemotaxis; negative regulation of cell volume; phospholipid scrambling; pore complex biogenesis; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of phagocytosis, engulfment

Anoctamin-7

Also known as Anoctamin-7 (Dresden transmembrane protein of the prostate) (D-TMPP) (IPCA-5) (New gene expressed in prostate) (Prostate cancer-associated protein 5) (Transmembrane protein 16G).
ANO7: May act as a calcium-activated chloride channel. May play a role in cell-cell interactions. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Calcium-binding; Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: endoplasmic reticulum; intracellular; plasma membrane

Molecular Function: intracellular calcium activated chloride channel activity

Biological Process: chloride transport

Anoctamin-8

Also known as Anoctamin-8 (Transmembrane protein 16H).
ANO8: May act as a calcium-activated chloride channel. Belongs to the anoctamin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Cellular Component: intracellular; plasma membrane

Molecular Function: intracellular calcium activated chloride channel activity; phospholipid scramblase activity

Biological Process: chloride transport

Anoctamin-9

Also known as Anoctamin-9 (Transmembrane protein 16J).
ANO9: May act as a calcium-activated chloride channel. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Cellular Component: intracellular; plasma membrane

Molecular Function: intracellular calcium activated chloride channel activity; phospholipid scramblase activity

Biological Process: chloride transport
Proteins Root Name Listing
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