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AP-1 complex

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Also involved in early steps of phagocytosis and macropinocytosis.

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AP-1 complex subunit beta

Also known as AP-1 complex subunit beta (Adaptor protein complex AP-1 subunit beta) (Adaptor-related protein complex 1 subunit beta) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain).
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Also involved in early steps of phagocytosis and macropinocytosis.

AP-1 complex subunit beta-1

Also known as AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit).
AP1B1: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes large subunit family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: trans-Golgi network

Molecular Function: protein binding; protein kinase binding

Biological Process: clathrin cage assembly; determination of left/right symmetry; heart development; intracellular protein transport; vesicle-mediated transport

AP-1 complex subunit gamma

Also known as AP-1 complex subunit gamma (Adaptor protein complex AP-1 subunit gamma) (Adaptor-related protein complex 1 subunit gamma) (Clathrin assembly protein complex 1 gamma large chain) (Gamma1-adaptin).
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Also involved in early steps of phagocytosis and macropinocytosis.

AP-1 complex subunit gamma-1

Also known as AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 large subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (At-g-Ad) (At-gamma-Ad) (Gamma-adaptin 1).
Encodes large subunit of the heterotetrameric adaptor protein complex AP-1. AP-1 is required for clathrin coated vesicles budding from the trans-Golgi network or plasma membrane

AP-1 complex subunit gamma-2

Also known as AP-1 complex subunit gamma-2 (Adaptor protein complex AP-1 large subunit gamma-2) (Adaptor-related protein complex 1 subunit gamma-2) (Clathrin assembly protein complex 1 gamma-2 large chain) (Gamma-adaptin 2).
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting at the trans-Golgi network and early endosomes (TGN/EE). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules ().

AP-1 complex subunit gamma-like 2

Also known as AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad).
AP1G2: May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV). Belongs to the adaptor complexes large subunit family.

Protein type: Adaptor/scaffold

Cellular Component: Golgi-associated vesicle; membrane; trans-Golgi network; transport vesicle

Molecular Function: protein binding

Biological Process: intracellular protein transport; vesicle-mediated transport

AP-1 complex subunit mu

Also known as AP-1 complex subunit mu (AP-1 adaptor complex mu1 subunit) (Adaptor protein complex AP-1 subunit mu) (Adaptor-related protein complex 1 subunit mu) (Clathrin-adaptor medium chain Apm1) (Mu1-adaptin).
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Also involved in early steps of phagocytosis and macropinocytosis.

AP-1 complex subunit mu-1

Also known as AP-1 complex subunit mu-1 (Adaptor protein complex AP-1 subunit mu-1) (Adaptor protein-1 mu-adaptin 1) (Adaptor-related protein complex 1 subunit mu-1) (At-muB1-Ad) (Clathrin assembly protein complex 1 mu-1 medium chain) (Mu1-adaptin 1).
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting at the trans-Golgi network and early endosomes (TGN/EE). The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Functions redundantly with AP1M2 in multiple post-Golgi trafficking pathways leading from the TGN to the vacuole, the plasma membrane, and the cell-division plane.

AP-1 complex subunit mu-1-I

Also known as AP-1 complex subunit mu-1-I (Clathrin assembly protein complex 1 mu-1-I medium chain) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor AP-1 47 kDa protein) (HA1 47 kDa subunit) (Mu1-I-adaptin) (Uncoordinated protein 101).
Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Ap47 is a subunit of the plasma membrane adaptor.

AP-1 complex subunit mu-2

Also known as AP-1 complex subunit mu-2 (Adaptor protein complex AP-1 subunit mu-2) (Adaptor protein-1 mu-adaptin 2) (Adaptor-related protein complex 1 subunit mu-2) (At-muB2-Ad) (Clathrin assembly protein complex 1 mu-2 medium chain) (Mu1-adaptin 2) (Protein HAPLESS 13).
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting at the trans-Golgi network and early endosomes (TGN/EE). The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Required for KNOLLE localization at the cell plate to mediate cytokinesis. Functions redundantly with AP1M1 in multiple post-Golgi trafficking pathways leading from the TGN to the vacuole, the plasma membrane, and the cell-division plane.

AP-1 complex subunit sigma-1

Also known as AP-1 complex subunit sigma-1 (Adaptor AP-1 19 kDa protein) (Adaptor protein complex AP-1 sigma-1 subunit) (Adaptor-related protein complex 1 sigma-1 subunit) (Clathrin assembly protein complex 1 sigma-1 small chain) (Clathrin assembly small subunit protein AP19-1) (AtAP19-1) (Sigma 1 subunit of AP-1 clathrin) (Sigma-adaptin 1) (Sigma1-adaptin).
Encodes clathrin assembly protein AP19.

AP-1 complex subunit sigma-1A

Also known as AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin).
AP1S1: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes small subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: AP-1 adaptor complex; cytoplasmic vesicle membrane; cytosol; Golgi apparatus; Golgi membrane; intracellular membrane-bound organelle; lysosomal membrane; membrane; trans-Golgi network membrane

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; receptor-mediated endocytosis; regulation of defense response to virus by virus; response to virus

Disease: Mental Retardation, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, And Keratoderma

AP-1 complex subunit sigma-2

Also known as AP-1 complex subunit sigma-2 (Adaptor AP-1 19 kDa protein) (Adaptor protein complex AP-1 sigma-2 subunit) (Adaptor-related protein complex 1 sigma-2 subunit) (Clathrin assembly protein complex 1 sigma-2 small chain) (Clathrin assembly small subunit protein AP19-2) (AtAP19-2) (Sigma 2 subunit of AP-1 clathrin) (Sigma-adaptin 2) (Sigma2-adaptin).
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting at the trans-Golgi network and early endosomes (TGN/EE). The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules ().

AP-1 complex subunit sigma-3

Also known as AP-1 complex subunit sigma-3 (Adaptor protein complex AP-1 subunit sigma-1C) (Adaptor-related protein complex 1 subunit sigma-1C) (Clathrin assembly protein complex 1 sigma-1C small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Sigma 1C subunit of AP-1 clathrin) (Sigma-adaptin 1C) (Sigma1C-adaptin).
AP1S3: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes small subunit family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Vesicle

Chromosomal Location of Human Ortholog: 2q36.1

Cellular Component: cytoplasmic vesicle membrane; cytosol; Golgi membrane; lysosomal membrane; trans-Golgi network membrane

Molecular Function: protein binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; protein targeting; regulation of defense response to virus by virus

Disease: Psoriasis 15, Pustular, Susceptibility To

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