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AP-4 complex

Part of the AP-4 complex, an adaptor-related complex which might be implicated in vesicular transport between intracellular compartments appearing upon cell differentiation such as prespore vesicles (PSVs).

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AP-4 complex subunit beta

Also known as AP-4 complex subunit beta (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta) (Beta subunit of AP-4) (Beta4-adaptin).
Part of the AP-4 complex, an adaptor-related complex which might be implicated in vesicular transport between intracellular compartments appearing upon cell differentiation such as prespore vesicles (PSVs).

AP-4 complex subunit beta-1

Also known as AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin).
AP4B1: Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Defects in AP4B1 are the cause of cerebral palsy spastic quadriplegic type 5 (CPSQ5). CPSQ5 is a neurodevelopmental disorder characterized by neonatal hypotonia that progresses to hypertonia and spasticity, and severe mental retardation with poor or absent speech development. Belongs to the adaptor complexes large subunit family.

Protein type: Adaptor/scaffold

Cellular Component: trans-Golgi network

Biological Process: intracellular protein transport; vesicle-mediated transport

AP-4 complex subunit epsilon

Also known as AP-4 complex subunit epsilon (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon) (Epsilon subunit of AP-4) (Epsilon-adaptin).
Part of the AP-4 complex, an adaptor-related complex which might be implicated in vesicular transport between intracellular compartments appearing upon cell differentiation such as prespore vesicles (PSVs).

AP-4 complex subunit epsilon-1

Also known as AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin).
AP4E1: Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Defects in AP4E1 are the cause of cerebral palsy spastic quadriplegic type 4 (CPSQ4). A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest motor and posture impairments often associated with epilepsy and disturbances of cognition, behavior, sensation, and communication. Belongs to the adaptor complexes large subunit family.

Protein type: Adaptor/scaffold

Cellular Component: trans-Golgi network

Biological Process: intracellular protein transport; vesicle-mediated transport

AP-4 complex subunit mu

Also known as AP-4 complex subunit mu (Adaptor protein complex AP-4 subunit mu) (Adaptor protein-4 mu-adaptin) (Adaptor-related protein complex 4 subunit mu) (At-muC-Ad) (Mu4-adaptin).
Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

AP-4 complex subunit mu-1

Also known as AP-4 complex subunit mu-1 (AP-4 adaptor complex mu subunit) (Adaptor-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4).
AP4M1: Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Defects in AP4M1 are the cause of cerebral palsy spastic quadriplegic type 3 (CPSQ3). A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals present postnatally with early infantile hypotonia, delayed psychomotor development, strabismus, lack of independent walking and severe mental retardation. They develop progressive spasticity of all limbs with generalized hypertonia, hyperreflexia, and extensor plantar responses by the end of the first year of life. Speech is absent or limited. Pseudobulbar signs, such as drooling, stereotypic laughter, and exaggerated jaw jerk, are part of the clinical picture. Belongs to the adaptor complexes medium subunit family.

Protein type: Adaptor/scaffold

Cellular Component: trans-Golgi network

Biological Process: Golgi to endosome transport; intracellular protein transport; vesicle-mediated transport

AP-4 complex subunit sigma

Also known as AP-4 complex subunit sigma (AP-4 adaptor complex subunit sigma) (Adaptor-related protein complex 4 subunit sigma) (Sigma subunit of AP-4) (Sigma4-adaptin).
Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

AP-4 complex subunit sigma-1

Also known as AP-4 complex subunit sigma-1 (AP-4 adaptor complex subunit sigma-1) (Adaptor-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin).
Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

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