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AP-5 complex

As part of AP-5, a probable fifth adaptor protein complex, it may be involved in endosomal transport.

Below are the list of possible AP-5 complex products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

AP-5 complex subunit beta-1

Also known as AP-5 complex subunit beta-1 (Adaptor-related protein complex 5 beta subunit) (Beta5).
As part of AP-5, a probable fifth adaptor protein complex, it may be involved in endosomal transport.

AP-5 complex subunit mu-1

Also known as AP-5 complex subunit mu-1 (Adaptor-related protein complex 5 subunit mu-1) (Mu5).
As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.

AP-5 complex subunit sigma-1

Also known as AP-5 complex subunit sigma-1 (Adaptor-related protein complex 5 sigma subunit) (Sigma5).
AP5S1: As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed:20613862, it is required for efficient homologous recombination DNA double-strand break repair.

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: AP-type membrane coat adaptor complex; cytoplasm; late endosome; lysosome; nucleus

Molecular Function: protein binding

Biological Process: double-strand break repair via homologous recombination; endosome transport

AP-5 complex subunit zeta-1

Also known as AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5).
AP5Z1: As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. Defects in AP5Z1 are the cause of spastic paraplegia autosomal recessive type 48 (SPG48). A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Cellular Component: cytoplasm; nucleoplasm; nucleus

Biological Process: double-strand break repair via homologous recombination; endosome transport
Proteins Root Name Listing
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