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APC membrane recruitment protein

Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context (By similarity).

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APC membrane recruitment protein 1

Also known as APC membrane recruitment protein 1 (Amer1) (Protein FAM123B).
Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context ().

APC membrane recruitment protein 2

Also known as APC membrane recruitment protein 2 (Amer2) (Protein FAM123A).
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex ().

APC membrane recruitment protein 3

Also known as APC membrane recruitment protein 3 (Amer3) (Protein FAM123C).
FAM123C: Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane. Belongs to the Amer family.

Protein type: Unknown function

Cellular Component: plasma membrane

Molecular Function: beta-catenin binding; phosphatidylinositol-4,5-bisphosphate binding

Biological Process: anatomical structure development
Proteins Root Name Listing
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