Hormone required during early development for endoderm differentiation and heart morphogenesis by acting as a ligand for the apelin receptor (APLNR). Acts as a motogen by promoting endoderm and mesendoderm cell migration during gastrulation by binding and activating the apelin receptor, thereby driving internalization of the apelin receptor. Plays a key role during heart development by acting as a ligand for the apelin receptor (By similarity).
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APELA: Hormone required for endoderm differentiation and heart morphogenesis. Acts as a ligand for the apelin receptor (APLNR) during heart development. Belongs to the Elabela family. Interacts with APLNR
Chromosomal Location of Human Ortholog: 4q32
Cellular Component: extracellular region
Molecular Function: apelin receptor binding; hormone activity
Biological Process: apelin receptor signaling pathway; endoderm development; heart development
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