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Apolipoprotein

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).

Below are the list of possible Apolipoprotein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the reer's specifications.

Apolipoprotein A-I

Also known as Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1).
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).

Apolipoprotein A-II

Also known as Apolipoprotein A-II (Apo-AII) (ApoA-II) (Antimicrobial peptide BAMP-1) (Apolipoprotein A2).
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. Has antimicrobial activity.

Apolipoprotein A-IV

Also known as Apolipoprotein A-IV (Apo-AIV) (ApoA-IV) (Apolipoprotein A4).
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

Apolipoprotein A-V

Also known as Apolipoprotein A-V (Apo-AV) (ApoA-V) (Apolipoprotein A5) (Regeneration-associated protein 3).
APOA5: Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Interacts with GPIHBP1. Up-regulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates). Liver and plasma. Belongs to the apolipoprotein A1/A4/E family.

Protein type: Lipid-binding; Secreted; Secreted, signal peptide

Cellular Component: chylomicron; extracellular region; extracellular space

Molecular Function: cholesterol binding; cholesterol transporter activity; enzyme activator activity; enzyme binding; heparin binding; lipid binding; low-density lipoprotein receptor binding; phosphatidylcholine binding; phospholipid binding

Biological Process: acylglycerol homeostasis; cholesterol biosynthetic process; cholesterol efflux; cholesterol homeostasis; lipid transport; lipoprotein metabolic process; neurite regeneration; phosphatidylcholine metabolic process; phospholipid efflux; positive regulation of fatty acid biosynthetic process; positive regulation of lipid catabolic process; positive regulation of lipoprotein lipase activity; regulation of cholesterol absorption; reverse cholesterol transport; triacylglycerol catabolic process; triacylglycerol metabolic process

Apolipoprotein B

Apolipoprotein B is a major protein constituent of chylomicrons, VLDL and LDL. It functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

Apolipoprotein B-100

Also known as Apolipoprotein B-100 (Apo B-100).
APOB: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Defects in APOB are a cause of familial hypobetalipoproteinemia type 1 (FHBL1). A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors. Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia.

Protein type: Carrier; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p24-p23

Cellular Component: actin cytoskeleton; cell soma; chylomicron; cytoplasm; cytosol; early endosome; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endosome membrane; extracellular region; extracellular space; Golgi apparatus; intracellular membrane-bound organelle; plasma membrane

Molecular Function: cholesterol transporter activity; heparin binding; low-density lipoprotein receptor binding; phospholipid binding; protein binding

Biological Process: cellular protein catabolic process; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; leukocyte migration; lipoprotein biosynthetic process; lipoprotein catabolic process; lipoprotein metabolic process; receptor-mediated endocytosis; response to virus; retinoid metabolic process

Disease: Hypercholesterolemia, Autosomal Dominant, Type B; Hypobetalipoproteinemia, Familial, 1

Apolipoprotein C-I

Also known as Apolipoprotein C-I (Apo-CI) (ApoC-I) (Apolipoprotein C1).
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.

Apolipoprotein C-I, basic form

Also known as Apolipoprotein C-I, basic form (Apo-CIB) (ApoC-IB) (Apolipoprotein C1B).
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.

Apolipoprotein C-II

Also known as Apolipoprotein C-II (Apo-CII) (ApoC-II) (Apolipoprotein C2).
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.

Apolipoprotein C-III

Also known as Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3).
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.

Apolipoprotein C-IV

Also known as Apolipoprotein C-IV (Apo-CIV) (ApoC-IV) (Apolipoprotein C2-linked) (ACL) (Apolipoprotein C4).
APOC4: May participate in lipoprotein metabolism. Belongs to the apolipoprotein C4 family.

Protein type: Secreted; Secreted, signal peptide

Molecular Function: lipid transporter activity

Apolipoprotein D

Also known as Apolipoprotein D (Apo-D) (ApoD).
may play a role in nerve repair in response to injury [RGD, Feb 2006]

Apolipoprotein E

Also known as Apolipoprotein E (Apo-E).
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues ().

Apolipoprotein Eb

Also known as Apolipoprotein Eb (Apo-Eb).
Associated with several classes of plasma lipoproteins, it mediates uptake of lipoproteins through its ability to interact with specific cell surface receptors.

Apolipoprotein F

Also known as Apolipoprotein F (Apo-F) (Leukemia virus-inactivating factor) (LVIF).
APOF: Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.

Protein type: Secreted; Secreted, signal peptide

Biological Process: cholesterol efflux; cholesterol metabolic process; triacylglycerol metabolic process

Apolipoprotein L1

Also known as Apolipoprotein L1 (Apolipoprotein L) (Apo-L) (ApoL) (Apolipoprotein L-I) (ApoL-I).
APOL1: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomerulosclerosis type 4 (FSGS4). It is a renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Belongs to the apolipoprotein L family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, chloride; Lipid-binding; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: extracellular region; extracellular space; intrinsic to membrane

Molecular Function: chloride channel activity; lipid binding; protein binding

Biological Process: cytolysis; innate immune response; killing of cells of another organism; receptor-mediated endocytosis

Disease: Focal Segmental Glomerulosclerosis 4, Susceptibility To

Apolipoprotein L2

Also known as Apolipoprotein L2 (Apolipoprotein L-II) (ApoL-II).
APOL2: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Belongs to the apolipoprotein L family.

Chromosomal Location of Human Ortholog: 22q12

Cellular Component: membrane

Disease: Schizophrenia

Apolipoprotein L3

Also known as Apolipoprotein L3 (Apolipoprotein L-III) (ApoL-III) (TNF-inducible protein CG12-1) (CG12_1).
APOL3: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Belongs to the apolipoprotein L family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: membrane

Molecular Function: lipid transporter activity; signal transducer activity

Biological Process: inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade

Apolipoprotein L4

Also known as Apolipoprotein L4 (Apolipoprotein L-IV) (ApoL-IV).
APOL4: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. Belongs to the apolipoprotein L family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid-binding; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 22q11.2-q13.2

Cellular Component: extracellular space; intracellular membrane-bound organelle

Disease: Schizophrenia

Apolipoprotein L5

Also known as Apolipoprotein L5 (Apolipoprotein L-V) (ApoL-V).
APOL5: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Belongs to the apolipoprotein L family.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 22q12.3

Apolipoprotein L6

Also known as Apolipoprotein L6 (Apolipoprotein L-VI) (ApoL-VI).
APOL6: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Belongs to the apolipoprotein L family.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 22q12.3

Apolipoprotein M

Also known as Apolipoprotein M (Apo-M) (ApoM).
Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid ().

Apolipoprotein R

Also known as Apolipoprotein R (Apo-R).
May be a lipoprotein-borne regulator of either the coagulation or the complement cascades.

Apolipoprotein

Also known as Apolipoprotein(a) (Apo(a)) (Lp(a)).
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.

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