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Apoptosis-inducing factor

Putative FAD-dependent oxidoreductase involved in the resistance to cercosporin and other singlet oxygen-generating photosensitizers. Translocates from mitochondria to the nucleus under apoptotic conditions, where it degrades DNA and induces apoptosis (By similarity).

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Apoptosis-inducing factor 1

Putative FAD-dependent oxidoreductase involved in the resistance to cercosporin and other singlet oxygen-generating photosensitizers. Translocates from mitochondria to the nucleus under apoptotic conditions, where it degrades DNA and induces apoptosis ().

Apoptosis-inducing factor 2

Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest ().

Apoptosis-inducing factor 3

Also known as Apoptosis-inducing factor 3 (Apoptosis-inducing factor-like protein).
AIFM3: Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential. Belongs to the FAD-dependent oxidoreductase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; EC 1.-.-.-; Endoplasmic reticulum; Mitochondrial; Oxidoreductase

Cellular Component: endoplasmic reticulum; mitochondrial inner membrane; mitochondrion
Proteins Root Name Listing
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