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Apoptosis-stimulating of p53 protein

Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.

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Apoptosis-stimulating of p53 protein 1

Also known as Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).
PPP1R13B: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Belongs to the ASPP family.

Protein type: Apoptosis; Protein phosphatase, regulatory subunit; Tumor suppressor

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane

Molecular Function: p53 binding; protein binding

Biological Process: negative regulation of cell cycle; regulation of apoptosis

Apoptosis-stimulating of p53 protein 2

Also known as Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2).
53BP2: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. Belongs to the ASPP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: cytoplasm; nucleoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: identical protein binding; NF-kappaB binding; p53 binding; protein binding; SH3/SH2 adaptor activity

Biological Process: negative regulation of cell cycle; regulation of apoptosis; signal transduction

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