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Arachidonate 12-lipoxygenase

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.

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Arachidonate 12-lipoxygenase, 12R-type

Also known as Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (Epidermis-type lipoxygenase 12).
ALOX12B: Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE). Defects in ALOX12B are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE). NCIE is a non- bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume. Belongs to the lipoxygenase family.

Protein type: EC 1.13.11.-; Lipid Metabolism - arachidonic acid; Oxidoreductase

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cytosol

Molecular Function: arachidonate 12-lipoxygenase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; protein binding

Biological Process: arachidonic acid metabolic process; ceramide biosynthetic process; hepoxilin biosynthetic process; linoleic acid metabolic process; lipoxygenase pathway; positive regulation of MAPKKK cascade; protein amino acid lipidation; sphingolipid metabolic process

Disease: Ichthyosis, Congenital, Autosomal Recessive 2

Arachidonate 12-lipoxygenase, 12S-type

Also known as Arachidonate 12-lipoxygenase, 12S-type (12S-LOX) (12S-lipoxygenase) (Lipoxin synthase 12-LO) (Platelet-type lipoxygenase 12).
ALOX12: Oxygenase and 14,15-leukotriene A4 synthase activity. Belongs to the lipoxygenase family.

Protein type: Apoptosis; EC 1.13.11.31; Lipid Metabolism - arachidonic acid; Oxidoreductase

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cytoplasm; cytosol; membrane; sarcolemma

Molecular Function: arachidonate 12-lipoxygenase activity; hepoxilin A3 synthase activity; hepoxilin-epoxide hydrolase activity; lipoxygenase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; protein binding

Biological Process: arachidonic acid metabolic process; cell motility; fatty acid oxidation; hepoxilin biosynthetic process; hepoxilin metabolic process; linoleic acid metabolic process; lipoxygenase pathway; negative regulation of apoptosis; positive regulation of angiogenesis; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation

Arachidonate 12-lipoxygenase, epidermal-type

Also known as Arachidonate 12-lipoxygenase, epidermal-type (12-LOX).
Non-heme iron-containing dioxygenase that probably catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. May preferentially convert arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE.
Proteins Root Name Listing
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