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Arf-GAP with dual PH domain-containing protein

GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

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Arf-GAP with dual PH domain-containing protein 1

Also known as Arf-GAP with dual PH domain-containing protein 1 (Centaurin-alpha-1) (Cnt-a1) (Putative MAPK-activating protein PM25).
CENTA1: GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

Protein type: GAPs; GAPs, ARF

Chromosomal Location of Human Ortholog: 7p22.3

Cellular Component: cytoplasm; nucleus; plasma membrane

Molecular Function: GTPase activator activity; inositol 1,3,4,5 tetrakisphosphate binding; protein binding

Biological Process: cell surface receptor linked signal transduction; regulation of GTPase activity

Arf-GAP with dual PH domain-containing protein 2

Also known as Arf-GAP with dual PH domain-containing protein 2 (Centaurin-alpha-2) (Cnt-a2).
CENTA2: GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, ARF; Lipid-binding; Mitochondrial

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: cytoplasm; mitochondrial envelope; plasma membrane

Molecular Function: inositol 1,3,4,5 tetrakisphosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding

Biological Process: heart development
Proteins Root Name Listing
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