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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein

GTPase-activating protein. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system (By similarity).

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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

Also known as Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2).
GTPase-activating protein. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system ().

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11

Also known as Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11 (AGAP-11) (Centaurin-gamma-like protein KIAA1975).
AGAP11: Putative GTPase-activating protein (Potential). Belongs to the centaurin gamma-like family.

Protein type: GAPs; GAPs, ARF

Chromosomal Location of Human Ortholog: 10q23.2

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

Also known as Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE).
CENTG1: a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins (GAPs). A GAP for ARF1 and ARF5. Two alternatively-spliced isoforms have been described. Isoform 1 is brain-specific, and isoform 2 is ubiquitously expressed, with highest levels in brain and heart. Isoform 1 participates to the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. Regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. The PH domains of isoforms 1 and 2 bind phospholipids, but they differentially regulate subcellular location. The PH domain of isoform 1 directs the protein to the nucleus, but the PH domain of isoform 2 directs it to the cytosol.

Protein type: GAPs; GAPs, ARF; Motility/polarity/chemotaxis; Tumor suppressor

Chromosomal Location of Human Ortholog: 12q14.1

Cellular Component: membrane; mitochondrion; nucleolus; nucleus

Molecular Function: protein binding

Biological Process: negative regulation of neuron apoptosis; negative regulation of protein catabolic process

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

Also known as Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1).
CENTG3: a member of the centaurin family of ADP-ribosylation factor directed (ARF) GTPase-activating proteins (GAPs). Protective against the pathogenesis of polyglutamine diseases. Mediates the nuclear translocation of the CENTG3-polyQ complexes and the formation of promyelocytic leukemia (PML) protein-associated nuclear bodies in reactive oxygen species (ROS) signaling. Promotes the degradation of polyQ proteins at PML nuclear bodies through the ubiquitin-proteasome pathway. Knockdown by small interfering RNA in neuronal cells consistently blocked the nuclear translocation of polyQ and enhanced polyQ-mediated cell death. Three alternatively-spliced isoforms have been described.

Protein type: GAPs; GAPs, ARF

Chromosomal Location of Human Ortholog: 7q36.1

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4

Also known as Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 (AGAP-4) (Centaurin-gamma-like family member 1) (Centaurin-gamma-like family member 5).
AGAP4: Putative GTPase-activating protein (Potential). Belongs to the centaurin gamma-like family.

Protein type: GAPs; GAPs, ARF

Chromosomal Location of Human Ortholog: 10q11.22

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5

Also known as Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 (AGAP-5) (Centaurin-gamma-like family member 2).
AGAP5: Putative GTPase-activating protein (Potential). Belongs to the centaurin gamma-like family.

Protein type: GAPs; GAPs, ARF

Chromosomal Location of Human Ortholog: 10q22.2

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6

Also known as Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6 (AGAP-6) (Centaurin-gamma-like family member 3).
CTGLF3: Putative GTPase-activating protein (Potential). Belongs to the centaurin gamma-like family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, ARF

Chromosomal Location of Human Ortholog: 10q11.23

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9

Also known as Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9 (AGAP-9) (Centaurin-gamma-like family member 6).
CTGLF6: Putative GTPase-activating protein (Potential). Belongs to the centaurin gamma-like family.

Protein type: GAPs; GAPs, ARF

Chromosomal Location of Human Ortholog: 10q11.22

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