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Arginine-glutamic acid dipeptide repeats protein

Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.

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Arginine-glutamic acid dipeptide repeats protein

Also known as Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).
RERE: Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. A chromosomal aberration involving RERE is found in the neuroblastoma cell line. Translocation t(1;15)(p36.2;q24). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription factor

Chromosomal Location of Human Ortholog: 1p36.23

Molecular Function: poly-glutamine tract binding; protein binding

Biological Process: NLS-bearing substrate import into nucleus

Disease: Neurodevelopmental Disorder With Or Without Anomalies Of The Brain, Eye, Or Heart

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