Also known as Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1). Involved in several behavioral responses including chemotaxis towards lysine and adaptation to repeated osmotic stress. In addition, plays a role in resuming egg-laying and locomotion after starvation.
Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.