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Arsenite methyltransferase

Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).

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Arsenite methyltransferase

Also known as Arsenite methyltransferase (Methylarsonite methyltransferase) (S-adenosyl-L-methionine:arsenic(III) methyltransferase).
AS3MT: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. Belongs to the methyltransferase superfamily.

Protein type: EC 2.1.1.137; Methyltransferase; Mitochondrial

Cellular Component: cytosol; mitochondrion

Molecular Function: arsenite methyltransferase activity; methylarsonite methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity

Biological Process: arsonoacetate metabolic process; methylation; response to arsenic; toxin metabolic process
Proteins Root Name Listing
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