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Aryl hydrocarbon receptor nuclear translocator

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens (By similarity). The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).

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Aryl hydrocarbon receptor nuclear translocator

Also known as Aryl hydrocarbon receptor nuclear translocator (ARNT protein).
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens (). The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia ().

Aryl hydrocarbon receptor nuclear translocator 2

Also known as Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).
ARNT2: Specifically recognizes the xenobiotic response element (XRE). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; DNA-binding; Transcription factor

Cellular Component: nucleus; transcription factor complex

Molecular Function: aryl hydrocarbon receptor binding; DNA binding; protein heterodimerization activity; transcription factor activity

Biological Process: brain development; central nervous system development; in utero embryonic development; negative regulation of apoptosis; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to hypoxia; response to toxin; response to xenobiotic stimulus

Aryl hydrocarbon receptor nuclear translocator homolog

Also known as Aryl hydrocarbon receptor nuclear translocator homolog (ARNT) (AHR-associated protein).
Has a role in cellular differentiation. Required for pharyngeal development. In collaboration with ahr-1 it is involved in RMEL/R and SDQR neuron cell migration. Acts in the cellular response to hypoxia. Involved in aggregation behavior by regulating soluble guanylate cyclase gene expression in the URX neurons.
Proteins Root Name Listing
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