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Arylamine N-acetyltransferase

Catalyzes the transfer of the acetyl group from acetyl coenzyme A to the free amino group of arylamines and hydrazines. Is able to utilize not only acetyl-CoA, but also n-propionyl-CoA and acetoacetyl-CoA as acyl donors, although at a lower rate. As acetyl-CoA and propionyl-CoA are products of cholesterol catabolism and the nat gene is likely present in the same operon than genes involved in cholesterol degradation, this enzyme could have a role in the utilization and regulation of these CoA species.

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Arylamine N-acetyltransferase

Also known as Arylamine N-acetyltransferase (NAT).
Catalyzes the transfer of the acetyl group from acetyl coenzyme A to the free amino group of arylamines and hydrazines. Is able to utilize not only acetyl-CoA, but also n-propionyl-CoA and acetoacetyl-CoA as acyl donors, although at a lower rate. As acetyl-CoA and propionyl-CoA are products of cholesterol catabolism and the nat gene is likely present in the same operon than genes involved in cholesterol degradation, this enzyme could have a role in the utilization and regulation of these CoA species.

Arylamine N-acetyltransferase 1

Also known as Arylamine N-acetyltransferase 1 (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N-acetyltransferase type 1) (NAT-1).
NAT1: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. Belongs to the arylamine N-acetyltransferase family.

Protein type: Acetyltransferase; EC 2.3.1.5; Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - other enzymes

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: cytosol

Molecular Function: arylamine N-acetyltransferase activity

Biological Process: xenobiotic metabolic process

Arylamine N-acetyltransferase 2

Also known as Arylamine N-acetyltransferase 2 (Arylamide acetylase 2) (N-acetyltransferase type 2) (AT-2) (NAT-2).
NAT1: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. Belongs to the arylamine N-acetyltransferase family.

Protein type: Acetyltransferase; EC 2.3.1.5; Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - other enzymes

Cellular Component: cytosol

Molecular Function: arylamine N-acetyltransferase activity; N-acetyltransferase activity

Biological Process: gut development; response to hypoxia; response to lipopolysaccharide; response to xenobiotic stimulus

Arylamine N-acetyltransferase 3

Also known as Arylamine N-acetyltransferase 3 (Arylamide acetylase 3) (N-acetyltransferase type 3) (NAT-3).
Nat3: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Belongs to the arylamine N-acetyltransferase family.

Protein type: EC 2.3.1.5

Cellular Component: plasma membrane

Molecular Function: L-amino acid transmembrane transporter activity

Biological Process: L-amino acid transport

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