Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.
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ASPH: Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. Belongs to the aspartyl/asparaginyl beta-hydroxylase family. 9 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 126.96.36.199; Membrane protein, integral; Oxidoreductase
Cellular Component: cytoplasm; endoplasmic reticulum; integral to membrane; plasma membrane
Molecular Function: peptide-aspartate beta-dioxygenase activity; protein binding
Biological Process: cytosolic calcium ion homeostasis; limb morphogenesis; negative regulation of cell proliferation; palate development; pattern specification process; peptidyl-aspartic acid hydroxylation; positive regulation of proteolysis; regulation of protein stability
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