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Astrotactin

Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development.

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Astrotactin-1

ASTN1: Neuronal adhesion molecule that is required for glial- guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum and olfactory bulb. Belongs to the astrotactin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q25.2

Astrotactin-2

ASTN2: a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. A deletion at this locus has been associated with schizophrenia. Multiple transcript variants encoding different proteins have been found for this locus. [provided by RefSeq, May 2010]

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: endosome; integral to membrane

Molecular Function: calcium ion binding; inositol 1,3,4,5 tetrakisphosphate binding; protein binding

Biological Process: establishment of body hair orientation

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