GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions.
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Protein type: EC 3.6.5.-; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: endoplasmic reticulum; integral to membrane; membrane
Molecular Function: identical protein binding; protein binding
Biological Process: endoplasmic reticulum organization and biogenesis; ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; protein homooligomerization
Disease: Neuropathy, Hereditary Sensory, Type If
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