ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
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ACLY: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. Homotetramer. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; EC 18.104.22.168; Lyase; Transferase
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: citrate lyase complex; cytoplasm; cytosol; membrane; nucleoplasm; plasma membrane
Molecular Function: ATP binding; ATP citrate synthase activity; protein binding
Biological Process: acetyl-CoA biosynthetic process; cholesterol biosynthetic process; citrate metabolic process; fatty acid biosynthetic process; lipid biosynthetic process; oxaloacetate metabolic process; positive regulation of cellular metabolic process
Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.
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