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ATP-dependent DNA helicase

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

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ATP-dependent DNA helicase 2 subunit 1

Also known as ATP-dependent DNA helicase 2 subunit 1 (ATP-dependent DNA helicase II 70 kDa subunit) (ATP-dependent DNA helicase II subunit Ku70) (Ku autoantigen protein p70 homolog).
Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching ().

ATP-dependent DNA helicase 2 subunit KU70

Also known as ATP-dependent DNA helicase 2 subunit KU70 (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit).
Ku80 and ku70 form the heterodimer complex Ku, required for proper maintenance of the telomeric C strand. Ku regulates the extension of the telomeric G strand. Interacts with WEX, and this interaction stimulates the WEX exonuclease activity.

ATP-dependent DNA helicase 2 subunit KU80

Also known as ATP-dependent DNA helicase 2 subunit KU80 (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit).
Ku80 and ku70 form the heterodimer complex Ku, required for proper maintenance of the telomeric C strand. Ku regulates the extension of the telomeric G strand. Interacts with WEX, and this interaction stimulates the WEX exonuclease activity. Binds double stranded DNA breaks as a heterodimer with Ku70, involved in non-homologous end joining repair. Mutants are defective in T-DNA integration. Over expression confers increased resistance to DNA damage agents and increased susceptibility to T-DNA transformation.

ATP-dependent DNA helicase chl1

Also known as ATP-dependent DNA helicase chl1 (Chromosome loss protein 1).
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G2/M (). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (). Has a specific role in chromosome segregation during meiosis II ().

ATP-dependent DNA helicase chl-1

Also known as ATP-dependent DNA helicase chl-1 (Chromosome loss protein homolog).
Required for normal cell proliferation and chromosome stability. Plays a role in DNA repair during replication.

ATP-dependent DNA helicase dda

DNA helicase that stimulates viral DNA replication and recombination. Plays a role in T4 DNA replication initiation by selecting and activating DNA origins. Acts by dissociating and reassociating with the DNA molecule being unwound. Unwinds DNA as a monomer in a 5'-to-3' direction at a rate of 250 bp/s and can efficiently displace proteins from the DNA.

ATP-dependent DNA helicase DDM1

Also known as ATP-dependent DNA helicase DDM1 (Protein CHROMATIN REMODELING 1) (AtCHR1) (CHR01) (Protein DECREASED DNA METHYLATION 1) (AtDDM1) (Protein SOMNIFEROUS 1) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin DDM1).
Protein is similar to SWI2/SNF2 chromatin remodeling proteins. DDM1 is appears to act as a chromatin-remodeling ATPase involved in cytosine methylation in CG and non-CG contexts. Involved in gene silencing and maintenance of DNA methylation and histone methylation. Hypomethylation of many genomic regions occurs in ddm1 mutants, and can cause several phenotypic abnormalities, but some loci, such as BONSAI (At1g73177) can be hypermethylated in ddm1 mutants after several generations, leading to different phenotypes. DDM1 might be involved in establishing a heterochromain boundary. A line expressing an RNAi targeted against DDM1 shows some resistance to agrobacterium-mediated root transformation.

ATP-dependent DNA helicase DDX11

Also known as ATP-dependent DNA helicase DDX11 (CHL1-related protein 1) (hCHLR1) (DEAD/H-box protein 11) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2).
DDX11: DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5' to 3' direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5'-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC (replication factor C) complex activities. Stimulates the flap endonuclease activity of FEN1. Required for normal sister chromatid cohesion. Required for recruitment of bovine papillomavirus type 1 regulatory protein E2 to mitotic chrmosomes and for viral genome maintenance. Required for maintaining the chromosome segregation and is essential for embryonic development and the prevention of aneuploidy. May function during either S, G2, or M phase of the cell cycle. Binds to both single- and double-stranded DNA. Defects in DDX11 are the cause of Warsaw breakage syndrome (WBRS). It is a syndrome characterized by severe microcephaly, pre- and postnatal growth retardation, facial dysmorphism and abnormal skin pigmentation. Additional features include high arched palate, coloboma of the right optic disk, deafness, ventricular septal defect, toes and fingers abnormalities. At cellular level, drug-induced chromosomal breakage, a feature of Fanconi anemia, and sister chromatid cohesion defects, a feature of Roberts syndrome, coexist. Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.13; Helicase; Nucleolus

Chromosomal Location of Human Ortholog: 12p11

Cellular Component: centrosome; midbody; nuclear chromatin; nucleolus; nucleoplasm; nucleus; spindle pole

Molecular Function: ATP-dependent DNA helicase activity; ATP-dependent helicase activity; chromatin binding; DNA binding; DNA replication origin binding; DNA-dependent ATPase activity; double-stranded DNA binding; G-quadruplex DNA binding; helicase activity; protein binding; RNA-dependent ATPase activity; single-stranded DNA binding; single-stranded RNA binding; triplex DNA binding

Biological Process: DNA duplex unwinding; negative regulation of protein binding; positive regulation of endodeoxyribonuclease activity; positive regulation of sister chromatid cohesion; replication fork processing; response to DNA damage stimulus; sister chromatid cohesion

Disease: Warsaw Breakage Syndrome

ATP-dependent DNA helicase fml1

Also known as ATP-dependent DNA helicase fml1 (FANCM-like protein 1).
ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops (PubMed:18851838, PubMed:22844101, PubMed:22723423). Plays a role in limiting crossover recombinantion during mitotic DNA double-strand break (DSB) repair (PubMed:18851838). Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (PubMed:18851838, PubMed:20347428, PubMed:24026537). FANCM-MHF also promotes non-crossover recombination in meiotic cells (PubMed:22723423, PubMed:24026537).

ATP-dependent DNA helicase hus2/rqh1

Has a role in the repair of UV-induced DNA damage in G2 via recombination-mediated repair. Also has a role in the repair of infrared-induced double DNA strand breaks. Exhibits an ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.

ATP-dependent DNA helicase II subunit 1

Also known as ATP-dependent DNA helicase II subunit 1 (ATP-dependent DNA helicase II subunit Ku70).
Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching ().

ATP-dependent DNA helicase II subunit 2

Also known as ATP-dependent DNA helicase II subunit 2 (ATP-dependent DNA helicase II subunit Ku80).
Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching ().

ATP-dependent DNA helicase MER3

Also known as ATP-dependent DNA helicase MER3 (Protein HFM1).
DNA-dependent ATPase. Required in the control of double strand breaks transition and crossover during meiosis. Unwinds DNA in the 3' TO 5' direction. Prefers single-stranded DNA.

ATP-dependent DNA helicase MER3 homolog

Also known as ATP-dependent DNA helicase MER3 homolog (Protein RICE MEIOTIC CROSSOVER 1).
DNA helicase required for crossover formation, complete synapsis of homologous chromosomes and bivalent formation during meiosis. Is specific to recombination events resulting in interference-sensitive crossovers (class I meiotic crossover) (PubMed:19470578, PubMed:19417775). Works cooperatively with ZIP4 to promote crossovers (PubMed:22393242).

ATP-dependent DNA helicase MPH1

Also known as ATP-dependent DNA helicase MPH1 (FANCM-like protein 1).
ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.

ATP-dependent DNA helicase P143

Essential for the initiation of viral DNA replication, it may contribute to other functions such as controlling the switch to the late phase and leading to the inhibition of host protein synthesis. Required for late and very late gene expression ().

ATP-dependent DNA helicase PcrA

DNA helicase. Has a broad nucleotide specificity, even being able to hydrolyze ethenonucleotides, and is able to couple the hydrolysis to unwinding of DNA substrates. It is a 3'-5' helicase but at high protein concentrations it can also displace a substrate with a 5' tail. Preferred substrate being one with both single and double-stranded regions of DNA.

ATP-dependent DNA helicase pfh1

Also known as ATP-dependent DNA helicase pfh1 (DNA repair and recombination helicase pfh1) (PIF1 helicase homolog) (RRM3/PIF1 homolog 1).
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Involved in the maintenance of mitochondrial (mtDNA). Required for both repair of mitochondrial DNA and recognition of a recombinogenic signal characterized by a 26-bp palindromic at sequence in the ery region of mitochondrial DNA. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. Required for the completion of S-phase.

ATP-dependent DNA helicase pif1

DNA-dependent ATPase and 5'-3' DNA helicase that efficiently unwinds G-quadruplex (G4) DNA structures. May be involved in resolving commom issues that arise during DNA replication, recombination, and repair.

ATP-dependent DNA helicase PIF2

Also known as ATP-dependent DNA helicase PIF2 (DNA repair and recombination helicase PIF2).
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability. Essential for replication of kinetoplast maxicircles, but not minicircles.

ATP-dependent DNA helicase PIF3

Also known as ATP-dependent DNA helicase PIF3 (DNA repair and recombination helicase PIF3).
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of genome stability.

ATP-dependent DNA helicase PIF4

Also known as ATP-dependent DNA helicase PIF4 (DNA repair and recombination helicase PIF4).
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability.

ATP-dependent DNA helicase PIF5

Also known as ATP-dependent DNA helicase PIF5 (DNA repair and recombination helicase PIF5).
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability. Involved in processing of minicircle Okazaki fragments.

ATP-dependent DNA helicase PIF6

Also known as ATP-dependent DNA helicase PIF6 (DNA repair and recombination helicase PIF6).
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of genome stability.

ATP-dependent DNA helicase PIF7

Also known as ATP-dependent DNA helicase PIF7 (DNA repair and recombination helicase PIF7).
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability.

ATP-dependent DNA helicase Q1

Also known as ATP-dependent DNA helicase Q1 (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1).
RECQL: DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Interacts with EXO1 and MLH1. High expression in heart, lung, skeletal muscle and kidney, low expression in brain. Belongs to the helicase family. RecQ subfamily.

Protein type: DNA repair, damage; EC 3.6.4.12; Helicase

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: chromosome; cytoplasm; membrane; nucleoplasm; nucleus

Molecular Function: ATP-dependent 3'-5' DNA helicase activity; ATP-dependent DNA helicase activity; DNA binding; DNA helicase activity; four-way junction helicase activity; protein binding

Biological Process: DNA repair; DNA strand renaturation; double-strand break repair via homologous recombination

ATP-dependent DNA helicase Q4

Also known as ATP-dependent DNA helicase Q4 (DNA helicase, RecQ-like type 4) (RecQ4) (RecQ protein-like 4).
RECQL4: DNA-dependent ATPase. May modulate chromosome segregation. Interacts with UBR1 and UBR2. Interacts with MCM10; this interaction regulates RECQL4 unwinding activity. Up-regulated in actively dividing cells. Ubiquitously expressed, with highest levels in thymus and testis. Belongs to the helicase family. RecQ subfamily.

Protein type: EC 3.6.4.12; Helicase

Cellular Component: chromosome; cytoplasm; membrane; nucleus

Molecular Function: ATP binding; ATP-dependent 3'-5' DNA helicase activity; bubble DNA binding; DNA binding; four-way junction helicase activity

Biological Process: base-excision repair; DNA duplex unwinding; DNA recombination; DNA replication; DNA strand renaturation; double-strand break repair; negative regulation of sister chromatid cohesion; pigmentation; positive regulation of cell proliferation; skeletal development; skeletal morphogenesis

ATP-dependent DNA helicase Q5

Also known as ATP-dependent DNA helicase Q5 (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5).
The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

ATP-dependent DNA helicase Q-like 4A

Also known as ATP-dependent DNA helicase Q-like 4A (RecQ-like protein 4A) (AtRecQ4A) (AtRecQl4A) (SGS1-like protein) (AtSGS1).
DNA helicase involved in the maintenance of genome stability by modulation of the DNA damage response and suppression of homologous recombination.

ATP-dependent DNA helicase RecG

Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) ().

ATP-dependent DNA helicase Rep

Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.

ATP-dependent DNA helicase RRM3

Also known as ATP-dependent DNA helicase RRM3 (Regulation of Ty1 transposition protein 104) (rDNA recombination mutation protein 3).
5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein-DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Needed for normal fork progression through over 1000 discrete sites scattered throughout the genome, like rDNA, tRNA genes, centromeres, active replication origins, or transcriptional silencers. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in regulation of Ty1 transposition and protects the genome from instability at nascent sites of retrotransposition. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G-quadruplex (G4) unwinding activity and can suppress G4-induced genome instability when PIF1 levels are low.

ATP-dependent DNA helicase srs2

ATP-dependent DNA helicase involved in DNA repair at least for UV-induced lesions. Also aids the recombinational repair of camptothecin-induced collapsed replication forks.

ATP-dependent DNA helicase SRS2-like protein At4g25120

Also known as ATP-dependent DNA helicase SRS2-like protein At4g25120 (AtSRS2).
ATP-dependent 3'- to 5'-DNA helicase that could disrupt recombinogenic DNA intermediates and facilitate single strand annealing. Unwinds nicked and partial Holliday junctions in vitro. Anneals two single strands into a dsDNA molecule in vitro.

ATP-dependent DNA helicase tlh1

Also known as ATP-dependent DNA helicase tlh1 (Sub-telomeric helicase RecQ homolog 1).
Exhibits ATP-dependent 3' to 5' DNA helicase activity and has a role in telomerase-independent telomere maintenance.

ATP-dependent DNA helicase tlh2

Also known as ATP-dependent DNA helicase tlh2 (Sub-telomeric helicase RecQ homolog 2).
Exhibits ATP-dependent 3' to 5' DNA helicase activity and has a role in telomerase-independent telomere maintenance. Represses ade6 at an ectopic site.

ATP-dependent DNA helicase UvrD1

DNA-dependent ATPase, acting on dsDNA with a 3'-ssDNA tail, unwinding with 3'-to 5'-polarity. A minimal tail of 18 nt is required for activity. Also highly efficient on nicked DNA. Involved in the post-incision events of nucleotide excision repair, as well as in nitrosative and oxidative stress response and possibly in persistence in the host. Inhibits RecA-mediated DNA strand exchange; this does not require ATPase activity. When combined with UvrA greatly inhibits RecA-mediated DNA strand exchange ().

ATP-dependent DNA helicase UvrD2

DNA-dependent ATPase, stimulated equally by ss-and dsDNA. Has both ATPase and helicase activities, and translocates along ssDNA displacing bound streptavidin. Its essentiality for growth does not depend on its helicase activity ().

ATP-dependent DNA helicase uvsW

Also known as ATP-dependent DNA helicase uvsW (Dar protein).
Plays important roles in recombination-dependent DNA repair and the reorganization of stalled replication forks during viral DNA synthesis.

ATP-dependent DNA helicase-like PIF8

Also known as ATP-dependent DNA helicase-like PIF8 (DNA repair and recombination protein PIF8).
Required for the maintenance of mitochondrial (kinetoplast) genome stability. Essential for cell viability. Has probably no helicase activity, missing at least two of seven conserved helicase motifs.
Proteins Root Name Listing
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