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ATP-dependent helicase

Essential replication protein, part of the primase-helicase required for lagging strand DNA synthesis. It acts processively. It forms a protein complex with the gene 59 protein that partly replaces the dda protein helicase function. Acts as single-stranded ATP-dependent DNA helicase.

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ATP-dependent helicase brm

Also known as ATP-dependent helicase brm (Homeotic gene regulator) (Protein brahma).
Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context.

ATP-dependent helicase fft1

Also known as ATP-dependent helicase fft1 (Fun thirty-related protein 1).
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization.

ATP-dependent helicase fft2

Also known as ATP-dependent helicase fft2 (Fun thirty-related protein 2).
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization.

ATP-dependent helicase fft3

Also known as ATP-dependent helicase fft3 (Fun thirty-related protein 3).
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization. Required for maintaining a heterochromatin chromatin structure at centromeres and subtelomeres by protecting these regions from euchromatin assembly. Enhances the nucleotide exchange activity of the pim1 guanine nucleotide exchange factor and abolishes histone-H3-mediated RanGAP inhibition. Involved in the construction of the centromeres.

ATP-dependent helicase FUN30

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs, facilitating single-stranded DNA (ssDNA) production by the EXO1 and SGS1 machinery. Promotes gene silencing at heterochromatin by regulating the chromatin structure within or around silent loci. Also required for heterochromatin organization at centromeres.

ATP-dependent helicase HRQ1

Also known as ATP-dependent helicase HRQ1 (Homologous to recQ protein 1).
Helicase with 3'-5' helicase activity involved in genome stability (PubMed:23456718, PubMed:24440721, PubMed:24700328). Functions in the RAD4-dependent nucleotide excision repair (NER) pathway and plays a critical role in DNA interstrand cross-link repair (PubMed:24440721, PubMed:24682993). Unwinds relatively long duplex DNA up to 120-bp and requires a long 3'-tail of at least 70 nucleotides for efficient unwinding of duplex DNA (PubMed:23026052). Activity is significantly stimulated by a preexisting fork structure (PubMed:24682993). Shows both processive helicase and DNA strand annealing activities (PubMed:24682993). Affects telomere length by a non-catalytic mechanism, probably through inhibiting telomerase by competing with it for ssDNA binding (PubMed:24440721).

ATP-dependent helicase NAM7

Also known as ATP-dependent helicase NAM7 (Nonsense-mediated mRNA decay protein 1) (Nuclear accommodation of mitochondria 7 protein) (Up-frameshift suppressor 1).
Probable helicase involved in mitochondrial functions. Required for rapid turnover of mRNAs containing a premature translational termination codon.

ATP-dependent helicase rhp16

Also known as ATP-dependent helicase rhp16 (DNA repair protein rhp16) (RAD16 homolog).
Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp7, after UV irradiation.

ATP-dependent helicase SGS1

Also known as ATP-dependent helicase SGS1 (Helicase TPS1).
ATP-dependent DNA helicase able to unwind duplex DNA or DNA- RNA heteroduplex (PubMed:9545297). Displacement of the DNA strand occurs in the 3' to 5' direction with respect to the single-stranded DNA flanking the duplex (PubMed:9545297). Acts as an integral component of the S-phase checkpoint response, which arrests cells due to DNA damage or blocked fork progression during DNA replication (PubMed:10640278). Can create a deleterious topological substrate that TOP3 preferentially resolves. The TOP3-SGS1 protein complex may function as a eukaryotic reverse gyrase introducing positive supercoils into extrachromosomal ribosomal DNA rings (PubMed:7969174). Together with topoisomerase II has a role in chromosomal segregation (PubMed:7736577). Maintains rDNA structure where it has a role in re-starting stalled replication forks (PubMed:12228808).

ATP-dependent helicase ULS1

Also known as ATP-dependent helicase ULS1 (Role in silencing protein 1) (Ubiquitin ligase for SUMO conjugates protein 1).
ATP-dependent helicase involved mating type switching and in silencing interference through its interaction with the silencing regulator SIR4. Cooperates with UBC4 and UBC5 to mediate ubiquitination of SUMO conjugates.

ATP-dependent helicase upf1

Also known as ATP-dependent helicase upf1 (Nonsense-mediated mRNA decay protein upf1) (Regulator of nonsense transcripts 1 homolog) (Up-frameshift suppressor 1).
Required for rapid turnover of mRNAs containing a premature translational termination codon.

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