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ATP-dependent RNA helicase

Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD-mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Positively regulates HIV-1 LTR-directed gene expression.

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ATP-dependent RNA helicase A

Also known as ATP-dependent RNA helicase A (RHA) (DEAH box protein 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II).
DDX9: a helicase that unwinds double-stranded DNA and RNA in a 3' to 5' direction. Interacts with the RNA-induced silencing complex (RISC) in human cells and functions in RISC loading. Generates multiple secondary structures that influence RNA-binding proteins. Has a dsRNA binding motif at the N-terminus, RGG-box at the carboxyl terminus, and a bidirectional nuclear transport domain of 110 amino acids at the carboxyl terminus. May play a role in X-linked gene expression.

Protein type: EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA processing; RNA splicing; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: centrosome; cytoplasm; cytosol; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex

Molecular Function: ATP-dependent DNA helicase activity; ATP-dependent RNA helicase activity; protein binding; RNA helicase activity

Biological Process: nuclear mRNA splicing, via spliceosome; osteoblast differentiation; positive regulation of interferon type I production; RNA processing

ATP-dependent RNA helicase bel

Also known as ATP-dependent RNA helicase bel (Protein belle).
ATP-dependent RNA helicase that is essential and required for cellular function, larval growth, and for male and female fertility. Also required for RNA interference (RNAi), double-stranded RNA induces potent and specific gene silencing, by acting downstream of dsRNA internalization. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger.

ATP-dependent RNA helicase cgh-1

Also known as ATP-dependent RNA helicase cgh-1 (Conserved germline helicase 1).
Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes.

ATP-dependent RNA helicase CshA

DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity (). Involved in cold tolerance, motility and alcohol tolerance.

ATP-dependent RNA helicase cyt-19

Also known as ATP-dependent RNA helicase cyt-19, mitochondrial.
Acts as an RNA chaperone to resolve non-native structures formed during RNA folding to promote mitochondrial group I, but also group II, intron splicing. Functions predominantly by disrupting accessible RNA secondary structure and depends on spontaneous openings in tightly packed RNAs to gain access to RNA helices.

ATP-dependent RNA helicase DBP1

ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes. Redundant to DED1, may be required in conditions in which DED1 expression is decreased ().

ATP-dependent RNA helicase DBP3

ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs ().

ATP-dependent RNA helicase dbp-3

ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs ().

ATP-dependent RNA helicase dbp5

ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription ().

ATP-dependent RNA helicase dbp-5

ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription ().

ATP-dependent RNA helicase dbp8

ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth ().

ATP-dependent RNA helicase dbp-8

ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth ().

ATP-dependent RNA helicase DbpA

DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes. Requires a single-stranded RNA loading site on the 3' side of the substrate helix.

ATP-dependent RNA helicase DDX1

Also known as ATP-dependent RNA helicase DDX1 (DEAD box protein 1).
Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Acts as a positive regulator of transcription. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Binds DNA and RNA. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit rtcb ().

ATP-dependent RNA helicase DDX18

Also known as ATP-dependent RNA helicase DDX18 (DEAD box protein 18).
DDX18: Probable RNA-dependent helicase. Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

Protein type: EC 3.6.4.13; Helicase; Nucleolus; RNA-binding

Cellular Component: chromosome; membrane; nucleolus

Molecular Function: ATP-dependent RNA helicase activity

Biological Process: RNA secondary structure unwinding

ATP-dependent RNA helicase DDX19A

Also known as ATP-dependent RNA helicase DDX19A (DDX19-like protein) (DEAD box protein 19A).
DDX19A: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.

Protein type: EC 3.6.4.13; Helicase

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cytoplasm; membrane; nucleus

Molecular Function: ATP-dependent RNA helicase activity; protein binding

Biological Process: mRNA export from nucleus; RNA secondary structure unwinding

ATP-dependent RNA helicase DDX19B

Also known as ATP-dependent RNA helicase DDX19B (DEAD box RNA helicase DEAD5) (DEAD box protein 19B).
DDX19B: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.13; Helicase; RNA-binding

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cytoplasm; membrane; nucleus

Molecular Function: ATP-dependent RNA helicase activity; helicase activity; protein binding

Biological Process: mRNA export from nucleus; RNA secondary structure unwinding

ATP-dependent RNA helicase DDX24

Also known as ATP-dependent RNA helicase DDX24 (DEAD box protein 24).
DDX24: ATP-dependent RNA helicase (Potential). Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.

Protein type: EC 3.6.4.13; Helicase

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: membrane; nucleolus

Molecular Function: ATP-dependent RNA helicase activity

Biological Process: RNA secondary structure unwinding

ATP-dependent RNA helicase DDX25

Also known as ATP-dependent RNA helicase DDX25 (DEAD box protein 25).
ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development ().

ATP-dependent RNA helicase DDX39A

Also known as ATP-dependent RNA helicase DDX39A (DEAD box protein 39).
DDX39: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus. Belongs to the DEAD box helicase family. DECD subfamily.

Protein type: EC 3.6.4.13; Helicase; RNA splicing; RNA-binding

Cellular Component: cytoplasm; membrane; nucleus; spliceosome

Molecular Function: ATP-dependent RNA helicase activity; ATPase activity

Biological Process: mRNA export from nucleus; nuclear mRNA splicing, via spliceosome; regulation of gene expression; response to DNA damage stimulus; RNA secondary structure unwinding

ATP-dependent RNA helicase DDX3X

Also known as ATP-dependent RNA helicase DDX3X (D1Pas1-related sequence 2) (DEAD box RNA helicase DEAD3) (mDEAD3) (DEAD box protein 3, X-chromosomal) (Embryonic RNA helicase).
DDX3: a multifunctional DEAD box family RNA helicase with diverse cellular functions. DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), and are involved in several steps of gene expression, such as transcription, maturation of nuclear and mitochondrial mRNA, mRNA export, translation initiation, and ribosome and spliceosome assembly. DDX3 is required for nuclear export of HIV-1 viral transcripts, possibly in a complex with the viral Rev protein and host cofactor CRM1. DDX3 is required for hepatitis C virus (HCV) RNA replication and its expression is downregulated in hepatitis B virus (HBV) associated hepatocellular carcinoma (HCC). May function as a tumor suppressor protein. Its expression inhibits tumor cell colony formation and increases expression of the cdk inhibitor p21 Waf1/Cip1. Low DDX3 expression has been shown in HCC, and aberrant subcellular localization occurs in many squamous cell carcinomas. Reduced DDX3 expression in cultured cells causes a diminished dependence on serum for cell proliferation and changes in cyclin D1 and p21 Waf1/Cip1 expression. Associates with eIF4F to promote translation of selected mRNAs. Is phosphorylated by the mitotic cyclin dependent kinase, cyclin B/cdc2. This phosphorylation may cause a loss of DDX3 function and a concomitant repression of ribosome biogenesis and translation in mitosis. Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFN-beta induction. Involved in regulation of apoptosis. May be required for activation of the intrinsic but inhibit activation of the extrinsic apoptotic pathway. Regulated by the cell cycle. Maximally expressed in the cytoplasm during G1/S phase and decreased expression during G2/M phase. Located predominantly in nuclear speckles and, at low levels, throughout the cytoplasm. Associates with the outer side of nuclear pore complexes (NPC) and mitochondrial outer membranes. Shuttles between the nucleus and the cytoplasm in an exportin1-dependent manner. Associates with polyadenylated mRNAs in the cytoplasm and the nucleus. Predominantly located in nucleus during G0 phase and in the cytoplasm during G1/S phase. Belongs to the DEAD box helicase family, DDX3 subfamily. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; EC 3.6.4.13; Helicase; RNA-binding; Spliceosome; Translation initiation

Cellular Component: cell-cell adherens junction; cytoplasm; eukaryotic translation initiation factor 3 complex; nucleus; stress granule

Molecular Function: ATP-dependent DNA helicase activity; ATP-dependent RNA helicase activity; ATPase activity; CTPase activity; DNA binding; eukaryotic initiation factor 4E binding; GTPase activity; mRNA 5'-UTR binding; nucleoside-triphosphatase activity; poly(A) binding; ribosomal small subunit binding; RNA binding; transcription factor binding; translation initiation factor binding

Biological Process: chromosome segregation; induction of apoptosis via death domain receptors; innate immune response; mature ribosome assembly; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of cell growth; negative regulation of protein complex assembly; negative regulation of translation; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of translation; positive regulation of translational initiation; positive regulation of viral genome replication; regulation of gene expression; response to virus; RNA secondary structure unwinding; stress granule assembly; translational initiation; Wnt receptor signaling pathway

ATP-dependent RNA helicase DDX3Y

Also known as ATP-dependent RNA helicase DDX3Y (D1Pas1-related sequence 1) (DEAD box protein 3, Y-chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2).
DDX3Y: a Y-linked DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. DBY mutations causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a key role in the spermatogenic process. Two alternatively spliced transcripts differ only in the length of the 3' UTR.

Protein type: EC 3.6.4.13; Helicase; RNA-binding

Cellular Component: cytoplasm; membrane

Molecular Function: ATP-dependent RNA helicase activity

Biological Process: chromosome segregation; regulation of gene expression; RNA secondary structure unwinding; translational initiation

ATP-dependent RNA helicase DDX50

Also known as ATP-dependent RNA helicase DDX50 (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2).
DDX50: an RNA helicase of the DEAD-box family.

Protein type: EC 3.6.4.13; Helicase; Nucleolus; RNA-binding

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: membrane; nucleolus; plasma membrane

Molecular Function: ATP-dependent RNA helicase activity

Biological Process: RNA secondary structure unwinding

ATP-dependent RNA helicase DDX51

Also known as ATP-dependent RNA helicase DDX51 (DEAD box protein 51).
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.

ATP-dependent RNA helicase DDX54

Also known as ATP-dependent RNA helicase DDX54 (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54).
DDX54: Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA processing; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 12q24.13

Cellular Component: membrane; nucleolus; nucleus

Molecular Function: ATP-dependent RNA helicase activity; estrogen receptor binding; receptor binding; transcription corepressor activity

Biological Process: estrogen receptor signaling pathway; RNA metabolic process; RNA processing; RNA secondary structure unwinding

ATP-dependent RNA helicase ddx6

Also known as ATP-dependent RNA helicase ddx6 (ATP-dependent RNA helicase p54) (P54H) (Xp54) (DEAD box protein 6).
ATP-dependent RNA helicase that is an integral component of messenger ribonucleoprotein complexes (mRNPs), storage particles that mask maternal mRNAs from the translational apparatus during oocyte maturation.

ATP-dependent RNA helicase DeaD

Also known as ATP-dependent RNA helicase DeaD (Cold-shock DEAD box protein A).
DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

ATP-dependent RNA helicase DEAH13

Also known as ATP-dependent RNA helicase DEAH13 (Protein FASCIATED STEM 4) (AtFAS4).
Over-expression of this gene results in stem fasciation. The predicted amino acid sequence reveals the presence of two domains (DEXH-box or DEAD-box helicase and DUF1065 domain) and fragments of two more domains (HrpA domain and HA2 domain).

ATP-dependent RNA helicase ded1

ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes ().

ATP-dependent RNA helicase DHH1

ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export ().

ATP-dependent RNA helicase dhx29

Also known as ATP-dependent RNA helicase dhx29 (DEAH box protein 29).
ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.

ATP-dependent RNA helicase DHX36

Also known as ATP-dependent RNA helicase DHX36 (DEAH box protein 36) (G4-resolvase 1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE).
DHX36: Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. Belongs to the DEAD box helicase family. DEAH subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding

Chromosomal Location of Human Ortholog: 3q25.2

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: ATP-dependent RNA helicase activity; DNA-dependent ATPase activity; double-stranded RNA binding; G-quadruplex DNA binding; histone deacetylase binding; protein binding

Biological Process: ossification; positive regulation of interferon type I production; positive regulation of telomere maintenance; positive regulation of transcription from RNA polymerase II promoter; RNA processing; RNA secondary structure unwinding

ATP-dependent RNA helicase DOB1

Also known as ATP-dependent RNA helicase DOB1 (mRNA transport regulator MTR4).
ATP-dependent RNA helicase required for the 3'-end formation of 5.8S RNA. Cofactor for the exosome complex that unwinds secondary structure in pre-rRNA. Required for nucleocytoplasmic transport of mRNA. May serve as a chaperone which translocates or normalizes the structure of mRNAs in preparation for export. Component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates.

ATP-dependent RNA helicase DQX1

Also known as ATP-dependent RNA helicase DQX1 (DEAQ box polypeptide 1).
DQX1: 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.12; Helicase

Cellular Component: cytoplasm; spliceosome

Molecular Function: ATP-dependent RNA helicase activity; ATPase activity

Biological Process: nuclear mRNA splicing, via spliceosome

ATP-dependent RNA helicase eIF4A

Also known as ATP-dependent RNA helicase eIF4A (Eukaryotic initiation factor 4A) (eIF-4A) (Stimulator factor I 37 kDa component) (Translation initiation factor 1/2) (p37).
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

ATP-dependent RNA helicase fal1

ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA ().

ATP-dependent RNA helicase HAS1

ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.

ATP-dependent RNA helicase has-1

ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.

ATP-dependent RNA helicase HCA4

Also known as ATP-dependent RNA helicase HCA4 (DEAD box protein 4) (Helicase CA4) (Helicase UF1).
ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2.

ATP-dependent RNA helicase mrh4

Also known as ATP-dependent RNA helicase mrh4, mitochondrial.
ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA ().

ATP-dependent RNA helicase MSS116

Also known as ATP-dependent RNA helicase MSS116, mitochondrial.
ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Also required for efficient mitochondrial translation ().

ATP-dependent RNA helicase mtr4

Component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates (). Required for heterochromatic gene silencing at centromeric repeats by either exosome- or RNAi-mediated degradation of heterochromatic transcripts.

ATP-dependent RNA helicase p62

Involved in RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys messenger RNAs homologous to the silencing trigger.

ATP-dependent RNA helicase RhlE

rhlE is transiently after a cold shock, dependent on the presence of PNPase. [More information is available at EcoGene: EG11235]. RhlE is a ribosome-associated factor that may be involved in ribosome maturation . [More information is available at EcoCyc: EG11235].

ATP-dependent RNA helicase ROK1

ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.

ATP-dependent RNA helicase sub2

ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity ().

ATP-dependent RNA helicase SUB2-1

ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity ().

ATP-dependent RNA helicase SUB2-2

ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity ().

ATP-dependent RNA helicase SUPV3L1

Also known as ATP-dependent RNA helicase SUPV3L1, mitochondrial (Suppressor of var1 3-like protein 1) (SUV3-like protein 1).
SUPV3L1: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. Belongs to the helicase family.

Protein type: DNA-binding; EC 3.6.4.13; Helicase; Mitochondrial; RNA-binding

Cellular Component: mitochondrial matrix; mitochondrion; nucleus

Molecular Function: ATP-dependent RNA helicase activity; DNA binding; DNA helicase activity; double-stranded RNA binding; protein homodimerization activity

Biological Process: DNA duplex unwinding; DNA recombination; negative regulation of apoptosis; positive regulation of cell growth; RNA catabolic process

ATP-dependent RNA helicase SUV3 homolog

Also known as ATP-dependent RNA helicase SUV3 homolog, mitochondrial.
ATPase and DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA and RNA/RNA duplexes in the 5'-3' direction.

ATP-dependent RNA helicase SUV3

Also known as ATP-dependent RNA helicase SUV3, mitochondrial.
Required for intron-independent turnover and processing of mitochondrial RNA. It is a key control element in nuclear-mitochondrial interactions (). Required for embedded hyphal growth, for wild-type respiratory growth, and biofilm development. Required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens. Plays am important role in virulence.

ATP-dependent RNA helicase SUV3L

Also known as ATP-dependent RNA helicase SUV3L, mitochondrial (OsSUV3L) (Protein SUPPRESSOR OF VAR 3-like).
Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates ().

ATP-dependent RNA helicase uap56

ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity. Links the mRNA adapter mlo3 to rae1 for targeting mRNA-protein complex to the proteins of the nucleoporin complex (NPC).

ATP-dependent RNA helicase VAD1

Also known as ATP-dependent RNA helicase VAD1 (Virulence-associated DEAD box protein 1).
ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (). Blocks autophagy in nutrient-rich conditions by, at least partly, binding and repressing the expression of a set of ATG genes, including ATG3, ATG7, ATG8, ATG19, ATG20 and ATG22 (PubMed:26098573). VAD1-mediated repression of autophagy is regulated by TOR-dependent phosphorylation of the decapping enzyme DCP2 (PubMed:26098573). Regulates multiple virulence-associated genes (PubMed:15765146). Repression of autophagy by VAD1 also regulates the pathogenesis (PubMed:26098573).

ATP-dependent RNA helicase vasa, isoform A

Also known as ATP-dependent RNA helicase vasa, isoform A (Antigen Mab46F11).
Involved in translational control mechanisms operating in early stages of oogenesis. Required maternally in many stages of oogenesis, including cystocyte differentiation, oocyte differentiation, and specification of anterior-posterior polarity in the developing cysts. Essential for the formation and/or structural integrity of perinuclear nuage particles during germ cell formation. Required for gus, Fsn and aub accumulation at the posterior pole of the embryo. Required for the localization of vas to the perinuclear region of nurse cells.

ATP-dependent RNA helicase WM6

Also known as ATP-dependent RNA helicase WM6 (DEAD box protein UAP56) (Dmrnahel) (HEL/UAP56).
Required for mRNA export out of the nucleus. Probable RNA helicase that may regulate entry into mitosis by down-regulating the expression of other genes whose activity may be rate-limiting for entry into mitosis during embryogenesis. Binds to salivary gland chromosomes and modifies position effect variegation. Promotes an open chromatin structure that favors transcription during development by regulating the spread of heterochromatin.

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