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ATPase family AAA domain-containing protein

ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner (By similarity).

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ATPase family AAA domain-containing protein 1

ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner ().

ATPase family AAA domain-containing protein 2

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation ().

ATPase family AAA domain-containing protein 2B

ATAD2B: a protein of the AAA ATPase family. Contains one bromo domain. Two alternatively-spliced isoforms have been described.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 2p24.1-p23.3

Cellular Component: nucleus

Molecular Function: ATPase activity; chromatin binding

Biological Process: negative regulation of chromatin silencing; positive regulation of transcription from RNA polymerase II promoter

ATPase family AAA domain-containing protein 3

Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. Important during development for the up-regulation of mitochondrial activity during the transition to higher larval stages. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability.

ATPase family AAA domain-containing protein 3A

ATAD3A: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone- dependent steroidogenesis. Belongs to the AAA ATPase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: mitochondrion

Biological Process: cell growth; negative regulation of apoptosis

Disease: Harel-yoon Syndrome

ATPase family AAA domain-containing protein 3-A

Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis ().

ATPase family AAA domain-containing protein 3-B

Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis ().

ATPase family AAA domain-containing protein 3B

Also known as ATPase family AAA domain-containing protein 3B (AAA-TOB3).
ATAD3B: May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes. Belongs to the AAA ATPase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 1p36.33

ATPase family AAA domain-containing protein 5

Also known as ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein).
ATAD5: Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis. Belongs to the AAA ATPase family. 2 isoforms of the human protein are produced by alternative splicing.

Biological Process: DNA replication during S phase; immunoglobulin production; positive regulation of B cell proliferation; positive regulation of isotype switching to IgG isotypes

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