Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein (By similarity).
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ATR-interacting protein Recombinant
ATR-interacting protein Antibody
ATRIP: is required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. Heterodimerizes with ATR. The heterodimer binds replication protein A (RPA), a protein complex that subsequently is recruited to single stranded DNA (ssDNA). Its EEXXXDDL motif is required for the interaction with catalytic subunit of DNA-PK and its recruitment to sites of DNA damage. e for this protein is either identical to or adjacent to that of ATRIP. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame. Three alternatively spliced human isoforms have been reported.
Protein type: Cell cycle regulation; DNA repair, damage; DNA-binding
Molecular Function: 3'-5' exonuclease activity
ATR-interacting protein mus304 Recombinant
ATR-interacting protein mus304 Antibody
DNA damage checkpoint protein required for chromosome break repair and for genomic stability during development.