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Aurora kinase

Part of a chromosomal passenger complex.

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Aurora kinase A

Also known as Aurora kinase A (Aurora 2) (Aurora family kinase 1) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threo.
AurA: a member of the AUR family of kinases. A cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines. Regulated by phosphorylation-dependent proteasomal degradation. Localized to mitotic centrosomes and spindle microtubules and is required for centrosome maturation. Loss of Aurora A leads to defective mitotic spindles and gross errors in chromosome segregation. Required for centrosome duplication and chromosome segregation. Overexpression in culture drives transformation and aneuploidy, and negatively regulates p53. Amplified or overexpressed in many tumors or cell lines. Found as a skin tumor susceptibility gene in mouse, and a human SNP in a degradation domain is weakly cancer-associated and undergoes allele-specific amplification. Inhibitors: VX-680, ZM447439, Hesperadin, SNS-595.

Protein type: AUR family; EC 2.7.11.1; Kinase, protein; Oncoprotein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)

Cellular Component: axon hillock; centrosome; condensed nuclear chromosome, pericentric region; germinal vesicle; microtubule cytoskeleton; microtubule organizing center; nucleus; perinuclear region of cytoplasm; pronucleus; spindle; spindle microtubule; spindle midzone; spindle pole centrosome

Molecular Function: histone serine kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ubiquitin protein ligase binding

Biological Process: anterior/posterior axis specification; centrosome localization; centrosome organization and biogenesis; meiosis; meiotic spindle organization and biogenesis; microtubule cytoskeleton organization and biogenesis; mitosis; mitotic cell cycle; mitotic centrosome separation; mitotic spindle organization and biogenesis; negative regulation of apoptosis; negative regulation of protein binding; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of cytokinesis; regulation of protein stability; response to wounding; spindle assembly involved in female meiosis I; spindle organization and biogenesis

Aurora kinase A-A

Also known as Aurora kinase A-A (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Serine/threonine-protein kinase 6-A) (Serine/threonine-protein kinase Eg2-A) (pEg2) (Serine/threonine-protein kinase aurora-A) (p46Eg265).
AurA: a member of the AUR family of kinases. A cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines. Regulated by phosphorylation-dependent proteasomal degradation. Localized to mitotic centrosomes and spindle microtubules and is required for centrosome maturation. Loss of Aurora A leads to defective mitotic spindles and gross errors in chromosome segregation. Required for centrosome duplication and chromosome segregation. Overexpression in culture drives transformation and aneuploidy, and negatively regulates p53. Amplified or overexpressed in many tumors or cell lines. Found as a skin tumor susceptibility gene in mouse, and a human SNP in a degradation domain is weakly cancer-associated and undergoes allele-specific amplification. Inhibitors: VX-680, ZM447439, Hesperadin, SNS-595.

Protein type: AUR family; EC 2.7.11.1; Kinase, protein; Oncoprotein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)

Aurora kinase A-B

Also known as Aurora kinase A-B (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Serine/threonine-protein kinase 6-B) (Serine/threonine-protein kinase Eg2-B) (Serine/threonine-protein kinase aurora-A) (p46XlEg22).
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Phosphorylates numerous target proteins. Important for microtubule formation and/or stabilization ().

Aurora kinase B

Also known as Aurora kinase B (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine.
AurB: a member of the AUR family of kinases. May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Expressed during S and G2/M phase and expression is upregulated in cancer cells during M phase. Localized to the midzone of central spindle in late anaphase and concentrated into the midbody in telophase and cytokinesis. Colocalizes with gamma tubulin in the mid-body. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Overexpressed in colorectal and other cancer cell lines and thought to cause aneuploidy via histone phosphorylation.

Protein type: AUR family; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)

Cellular Component: condensed nuclear chromosome, pericentric region; midbody; nucleus; spindle microtubule; spindle pole centrosome

Molecular Function: histone serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity

Biological Process: abscission; mitotic spindle organization and biogenesis; negative regulation of B cell apoptosis; negative regulation of cytokinesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cytokinesis; protein amino acid phosphorylation; spindle midzone assembly involved in mitosis

Aurora kinase B-A

Also known as Aurora kinase B-A (Aurora/IPL1-related kinase 2-A) (AIRK2-A) (XAIRK2-A) (Serine/threonine-protein kinase 12-A) (Serine/threonine-protein kinase aurora-B-A) (xAurora-B).
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Phosphorylates 'Ser-10' of histone H3 during mitosis.

Aurora kinase B-B

Also known as Aurora kinase B-B (Aurora/IPL1-related kinase 2-B) (AIRK2-B) (XAIRK2-B) (Serine/threonine-protein kinase 12-B) (Serine/threonine-protein kinase aurora-B-B) (xAurora-B-B).
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Phosphorylates 'Ser-10' of histone H3 during mitosis ().

Aurora kinase C

Also known as Aurora kinase C (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 1) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C).
AurC: a member of the AUR family of kinases. May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. Localized to centrosome from anaphase to cytokinesis. Two splice-variant isoforms have been described.

Protein type: AUR family; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)

Cellular Component: chromosome; chromosome, pericentric region; condensed chromosome; condensed nuclear chromosome, pericentric region; midbody; spindle microtubule; spindle midzone; spindle pole centrosome

Molecular Function: histone serine kinase activity; protein kinase activity; protein serine/threonine/tyrosine kinase activity

Biological Process: mitotic spindle organization and biogenesis; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cytokinesis

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