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Axin interactor, dorsalization-associated protein

Acts as a ventralizing factor during embryogenesis (By similarity). Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.

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Axin interactor, dorsalization-associated protein

Also known as Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist).
AIDA: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling. Belongs to the AIDA family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation

Cellular Component: cytoplasm; membrane

Molecular Function: phosphoinositide binding; protein binding; protein domain specific binding

Biological Process: determination of ventral identity; dorsal/ventral pattern formation; negative regulation of JNK activity; negative regulation of JNK cascade; negative regulation of Wnt receptor signaling pathway; regulation of protein homodimerization activity

Axin interactor, dorsalization-associated protein A

Also known as Axin interactor, dorsalization-associated protein A (Axin interaction partner and dorsalization antagonist A).
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by axin/JNK-signaling ().

Axin interactor, dorsalization-associated protein B

Also known as Axin interactor, dorsalization-associated protein B (Axin interaction partner and dorsalization antagonist B).
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by axin/JNK-signaling ().
Proteins Root Name Listing
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