Cytoplasmic tRNA 2-thiolation protein
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
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Cytoplasmic tRNA 2-thiolation protein 1
ATPBD3: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
Protein type: EC 2.7.7.-
Chromosomal Location of Human Ortholog: 19q13.41
Cellular Component: cytosol
Molecular Function: protein binding
Biological Process: tRNA modification
Cytoplasmic tRNA 2-thiolation protein 2
Cytoplasmic tRNA 2-thiolation protein 2-A
Cytoplasmic tRNA 2-thiolation protein 2-B
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