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Disintegrin and metalloproteinase domain-containing protein

May be involved in sperm-egg fusion.

Below are the list of possible Disintegrin and metalloproteinase domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the reer's specifications.

Disintegrin and metalloproteinase domain-containing protein 1

Also known as Disintegrin and metalloproteinase domain-containing protein 1 (ADAM 1) (Fertilin subunit alpha).
ADAM1A: May be involved in sperm-egg fusion.

Protein type: EC 3.4.24.-; Endoplasmic reticulum; Membrane protein, integral; Protease

Cellular Component: lipid raft

Biological Process: binding of sperm to zona pellucida; male gonad development

Disintegrin and metalloproteinase domain-containing protein 10

Also known as Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c).
ADAM10: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth- like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

Protein type: Cell adhesion; Cell surface; EC 3.4.24.81; Membrane protein, integral; Motility/polarity/chemotaxis; Protease; Vesicle

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: cell surface; cytoplasm; focal adhesion; Golgi apparatus; Golgi-associated vesicle; intracellular membrane-bound organelle; membrane; nucleus; plasma membrane

Molecular Function: endopeptidase activity; metalloendopeptidase activity; metallopeptidase activity; protein binding; protein homodimerization activity; protein kinase binding

Biological Process: constitutive protein ectodomain proteolysis; ephrin receptor signaling pathway; extracellular matrix disassembly; in utero embryonic development; membrane protein ectodomain proteolysis; monocyte activation; negative regulation of cell adhesion; Notch receptor processing; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; protein amino acid phosphorylation

Disease: Alzheimer Disease 18; Reticulate Acropigmentation Of Kitamura

Disintegrin and metalloproteinase domain-containing protein 11

Also known as Disintegrin and metalloproteinase domain-containing protein 11 (ADAM 11) (MDC11.1) (Metalloprotease-disintegrin MDC11a) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).
Probable ligand for integrin in the brain. This is a non-catalytic metalloprotease-like protein.

Disintegrin and metalloproteinase domain-containing protein 12

Also known as Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (Meltrin-alpha).
ADAM12: contains a disintegrin and metalloprotease (ADAM) domain 12, which is a member of the ADAM protein family. Involved in skeletal muscle regeneration, specifically at the onset of cell fusion, and the differentiation of macrophage-derived giant cells (MGC) and osteoclasts. 2 alternative splicing isoforms have been described: a shorter secreted form and a longer membrane-bound form. The shorter form stimulates myogenesis.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Cellular Component: mitochondrion; nucleoplasm; plasma membrane

Molecular Function: SH3 domain binding

Disintegrin and metalloproteinase domain-containing protein 15

Also known as Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (AD56) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin).
ADAM15: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Cellular Component: cell surface

Molecular Function: integrin binding; metallopeptidase activity; protein binding; SH3 domain binding

Biological Process: innate immune response; integrin-mediated signaling pathway; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell-matrix adhesion

Disintegrin and metalloproteinase domain-containing protein 17

Also known as Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b).
TACE: a type I membrane protein with disintegrin and metalloprotease activity. An ubiquitously expressed ectoenzyme of peptidase family M12B. Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Possesses a narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha) to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, and the amyloid precursor protein. Also involved in the activation of Notch pathway. Binds 1 zinc ion per subunit. Two splice variant isoforms have been described.

Protein type: EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: actin cytoskeleton; apical plasma membrane; cell surface; cytoplasm; focal adhesion; integral to plasma membrane; intercellular junction; lipid raft; membrane; plasma membrane

Molecular Function: integrin binding; interleukin-6 receptor binding; metalloendopeptidase activity; metallopeptidase activity; Notch binding; PDZ domain binding; protein binding

Biological Process: B cell differentiation; cell adhesion; cell adhesion mediated by integrin; cell motility involved in cell locomotion; defense response to Gram-positive bacterium; epidermal growth factor receptor signaling pathway; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; germinal center formation; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; negative regulation of transforming growth factor beta receptor signaling pathway; neutrophil mediated immunity; Notch receptor processing; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of chemokine production; positive regulation of epidermal growth factor receptor activity; positive regulation of leukocyte chemotaxis; positive regulation of protein amino acid phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; proteolysis; regulation of mast cell apoptosis; response to drug; response to high density lipoprotein stimulus; response to hypoxia; response to lipopolysaccharide; spleen development; T cell differentiation in the thymus; tumor necrosis factor-mediated signaling pathway; wound healing, spreading of epidermal cells

Disease: Inflammatory Skin And Bowel Disease, Neonatal, 1

Disintegrin and metalloproteinase domain-containing protein 18

Also known as Disintegrin and metalloproteinase domain-containing protein 18 (ADAM 18) (Disintegrin and metalloproteinase domain-containing protein 27) (ADAM 27) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III) (tMDC III).
ADAM18: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Molecular Function: integrin binding

Disintegrin and metalloproteinase domain-containing protein 19

Also known as Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (Meltrin-beta).
ADAM19: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Cellular Component: external side of plasma membrane; Golgi apparatus

Molecular Function: protein binding

Biological Process: heart development; membrane protein ectodomain proteolysis

Disintegrin and metalloproteinase domain-containing protein 1a

Also known as Disintegrin and metalloproteinase domain-containing protein 1a (ADAM 1a) (Fertilin subunit alpha-a).
ADAM1A: May be involved in sperm-egg fusion.

Protein type: EC 3.4.24.-; Endoplasmic reticulum; Membrane protein, integral; Protease

Cellular Component: lipid raft

Molecular Function: protein binding

Biological Process: binding of sperm to zona pellucida

Disintegrin and metalloproteinase domain-containing protein 1b

Also known as Disintegrin and metalloproteinase domain-containing protein 1b (ADAM 1b) (Fertilin subunit alpha-b).
ADAM1B: May play a role in spermatogenesis and sperm maturation.

Protein type: Cell surface; EC 3.4.24.-; Membrane protein, integral; Protease

Molecular Function: protein binding

Disintegrin and metalloproteinase domain-containing protein 2

Also known as Disintegrin and metalloproteinase domain-containing protein 2 (ADAM 2) (Cancer/testis antigen 15) (CT15) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta).
ADAM2: a member of the ADAM (a disintegrin and metalloprotease domain) family of Cancer-Testis Antigen (CTAs) . CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovary cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. A sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from RefSeq and UniProtKB

Protein type: Cancer Testis Antigen (CTA); Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: integrin binding; metallopeptidase activity

Biological Process: binding of sperm to zona pellucida; fusion of sperm to egg plasma membrane

Disintegrin and metalloproteinase domain-containing protein 20

Also known as Disintegrin and metalloproteinase domain-containing protein 20 (ADAM 20).
ADAM20: May be involved in sperm maturation and/or fertilization.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: plasma membrane

Molecular Function: metallopeptidase activity

Biological Process: binding of sperm to zona pellucida; single fertilization

Disintegrin and metalloproteinase domain-containing protein 21

Also known as Disintegrin and metalloproteinase domain-containing protein 21 (ADAM 21).
ADAM21: May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: plasma membrane

Molecular Function: metallopeptidase activity

Biological Process: binding of sperm to zona pellucida; single fertilization

Disintegrin and metalloproteinase domain-containing protein 22

Also known as Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22).
ADAM22: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Cellular Component: axon; integral to membrane

Molecular Function: protein binding

Biological Process: adult locomotory behavior; gliogenesis; myelination in the peripheral nervous system; Schwann cell differentiation

Disintegrin and metalloproteinase domain-containing protein 23

Also known as Disintegrin and metalloproteinase domain-containing protein 23 (ADAM 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3).
ADAM23: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Molecular Function: protein binding

Disintegrin and metalloproteinase domain-containing protein 25

Also known as Disintegrin and metalloproteinase domain-containing protein 25 (ADAM 25) (Testase-2).
ADAM25: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization.

Protein type: EC 3.4.24.-; Membrane protein, integral; Protease

Molecular Function: integrin binding; metallopeptidase activity

Disintegrin and metalloproteinase domain-containing protein 28

Also known as Disintegrin and metalloproteinase domain-containing protein 28 (ADAM 28) (Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (eMDC II).
May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.

Disintegrin and metalloproteinase domain-containing protein 29

Also known as Disintegrin and metalloproteinase domain-containing protein 29 (ADAM 29).
ADAM29: a member of the ADAM (a disintegrin and metalloprotease domain) family of Cancer-Testis Antigen (CTAs). CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins. May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein. Has been found to be frequently mutated in melanoma. Mutations may play a role in melanoma progression and metastasis. Expressed in leukemias at the mRNA level. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA); Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Disintegrin and metalloproteinase domain-containing protein 30

Also known as Disintegrin and metalloproteinase domain-containing protein 30 (ADAM 30).
ADAM30: May be involved in spermatogenesis and fertilization. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 1p12

Cellular Component: plasma membrane

Molecular Function: metallopeptidase activity; zinc ion binding

Biological Process: binding of sperm to zona pellucida

Disintegrin and metalloproteinase domain-containing protein 32

Also known as Disintegrin and metalloproteinase domain-containing protein 32 (ADAM 32).
ADAM32: May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 8p11.22

Disintegrin and metalloproteinase domain-containing protein 33

Also known as Disintegrin and metalloproteinase domain-containing protein 33 (ADAM 33).
ADAM33: Genetic variations in ADAM33 are associated with susceptibility to asthma (ASTHMA). The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 20p13

Disintegrin and metalloproteinase domain-containing protein 7

Also known as Disintegrin and metalloproteinase domain-containing protein 7 (ADAM 7).
ADAM7: May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein. Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Cellular Component: apical part of cell; plasma membrane

Molecular Function: endopeptidase activity

Disintegrin and metalloproteinase domain-containing protein 8

Also known as Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (Cell surface antigen MS2) (CD antigen CD156a).
ADAM8: Possible involvement in extravasation of leukocytes.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: cell surface; cytoplasm; dense core granule membrane; integral to plasma membrane; plasma membrane; podosome; specific granule

Molecular Function: calcium ion binding; cell adhesion molecule binding; metallopeptidase activity; protein binding; protein self-association; serine-type endopeptidase activity; zinc ion binding

Biological Process: activation of NF-kappaB transcription factor; angiogenesis; cell morphogenesis; extracellular matrix disassembly; inflammatory response; leukocyte migration during inflammatory response; lymphocyte chemotaxis; negative regulation of neuron apoptosis; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein kinase B signaling cascade; positive regulation of protein secretion; positive regulation of T cell differentiation in the thymus; regulation of cell-cell adhesion

Disintegrin and metalloproteinase domain-containing protein 9

Also known as Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase).
ADAM9: Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP. Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 8p11.22

Cellular Component: cell surface; extracellular space; focal adhesion

Molecular Function: collagen binding; integrin binding; laminin binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; protein kinase C binding; SH3 domain binding

Biological Process: activation of MAPKK activity; cell adhesion; cell adhesion mediated by integrin; cell migration; cell-cell adhesion mediated by integrin; cell-matrix adhesion; integrin-mediated signaling pathway; keratinocyte differentiation; membrane protein ectodomain proteolysis; monocyte activation; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell adhesion mediated by integrin; positive regulation of keratinocyte migration; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein secretion; response to calcium ion; response to glucocorticoid stimulus; response to hydrogen peroxide; response to manganese ion; transforming growth factor beta receptor signaling pathway

Disease: Cone-rod Dystrophy 9

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