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Endothelial transcription factor

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.

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Endothelial transcription factor GATA-2

Also known as Endothelial transcription factor GATA-2 (GATA-binding protein 2).
GATA2: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Cellular Component: nucleoplasm; nucleus; protein complex; transcription factor complex

Molecular Function: chromatin binding; DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding

Biological Process: cell differentiation; cell differentiation in hindbrain; cell fate determination; cell maturation; central nervous system neuron development; commitment of a neuronal cell to a specific type of neuron in the forebrain; elevation of cytosolic calcium ion concentration; embryonic placenta development; gut development; heart development; homeostasis of number of cells within a tissue; inner ear morphogenesis; negative regulation of fat cell differentiation; negative regulation of macrophage differentiation; negative regulation of myeloid cell differentiation; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; neuron fate commitment; neuron migration; pituitary gland development; positive regulation of angiogenesis; positive regulation of erythrocyte differentiation; positive regulation of mast cell degranulation; positive regulation of megakaryocyte differentiation; positive regulation of neuron differentiation; positive regulation of phagocytosis; positive regulation of phagocytosis, engulfment; positive regulation of transcription from RNA polymerase II promoter; regulation of histone acetylation; somatic stem cell maintenance; tissue development; transcription, DNA-dependent; urogenital system development; ventral spinal cord interneuron differentiation

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