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Estradiol 17 beta-dehydrogenase

Favors the reduction of estrogens and androgens. Uses preferentially NADH.

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Estradiol 17 beta-dehydrogenase 5

Also known as Estradiol 17 beta-dehydrogenase 5 (17-beta-HSD 5).
AKR1C4: Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. Defects in AKR1C4 are a cause of 46,XY sex reversal type 8 (SRXY8). A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. AKR1C4 mutations may act as modifier of disease severity in SRXY8 patients. A splicing mutation resulting in loss of exon 2 has been found in affected individuals also carrying mutation Val-79 in AKR1C2 (PubMed:21802064). Belongs to the aldo/keto reductase family.

Protein type: EC 1.1.1.225; EC 1.1.1.357; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Lipid Metabolism - primary bile acid biosynthesis; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450

Cellular Component: cytoplasm; nucleus

Molecular Function: 20-alpha-hydroxysteroid dehydrogenase activity; 3(or 17)-alpha-hydroxysteroid dehydrogenase activity; estradiol 17-beta-dehydrogenase activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; retinal dehydrogenase activity; testosterone 17-beta-dehydrogenase (NADP+) activity

Biological Process: negative regulation of nuclear mRNA splicing, via spliceosome; response to drug; response to estrogen stimulus; steroid metabolic process

Estradiol 17-beta-dehydrogenase 1

Also known as Estradiol 17-beta-dehydrogenase 1 (17-beta-hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1).
HSD17B1: Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: EC 1.1.1.62; Lipid Metabolism - androgen and estrogen; Oxidoreductase

Cellular Component: cytoplasm; cytosol; nuclear membrane; nucleoplasm

Molecular Function: 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity; estradiol 17-beta-dehydrogenase activity

Biological Process: estrogen biosynthetic process

Estradiol 17-beta-dehydrogenase 11

Also known as Estradiol 17-beta-dehydrogenase 11 (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Cutaneous T-cell lymphoma-associated antigen HD-.
HSD17B11: Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Protein type: EC 1.1.1.62; Oxidoreductase; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; lipid particle

Molecular Function: estradiol 17-beta-dehydrogenase activity; steroid dehydrogenase activity

Biological Process: androgen catabolic process; estrogen biosynthetic process

Estradiol 17-beta-dehydrogenase 2

Also known as Estradiol 17-beta-dehydrogenase 2 (17-beta-hydroxysteroid dehydrogenase type 2) (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reduct.
HSD17B2: Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: EC 1.1.1.239; EC 1.1.1.62; Endoplasmic reticulum; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: 16q24.1-q24.2

Cellular Component: endoplasmic reticulum membrane

Molecular Function: 20-alpha-hydroxysteroid dehydrogenase activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity; estradiol 17-beta-dehydrogenase activity

Biological Process: response to retinoic acid

Estradiol 17-beta-dehydrogenase 8

Also known as Estradiol 17-beta-dehydrogenase 8 (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (Protein Ke6.
HSD17B8: NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: EC 1.1.1.239; EC 1.1.1.62; Lipid Metabolism - androgen and estrogen; Mitochondrial; Oxidoreductase

Cellular Component: membrane; mitochondrial envelope; mitochondrial matrix; mitochondrion; plasma membrane

Molecular Function: 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity; 3-hydroxyacyl-CoA dehydrogenase activity; 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity; estradiol 17-beta-dehydrogenase activity

Biological Process: androgen metabolic process; estrogen biosynthetic process; estrogen metabolic process; fatty acid biosynthetic process; protein heterotetramerization

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