• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Leukocyte immunoglobulin-like receptor subfamily

May act as receptor for class I MHC antigens.

Below are the list of possible Leukocyte immunoglobulin-like receptor subfamily products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the reer's specifications.

Leukocyte immunoglobulin-like receptor subfamily A member 1

Also known as Leukocyte immunoglobulin-like receptor subfamily A member 1 (CD85 antigen-like family member I) (Leukocyte immunoglobulin-like receptor 6) (LIR-6) (CD antigen CD85i).
LILRA1: May act as receptor for class I MHC antigens. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: plasma membrane

Molecular Function: antigen binding; transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; defense response; regulation of immune response

Leukocyte immunoglobulin-like receptor subfamily A member 2

Also known as Leukocyte immunoglobulin-like receptor subfamily A member 2 (CD85 antigen-like family member H) (Immunoglobulin-like transcript 1) (ILT-1) (Leukocyte immunoglobulin-like receptor 7) (LIR-7) (CD antigen CD85h).
LILRA2: Does not bind class I MHC antigens. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.4

Molecular Function: antigen binding; receptor activity

Biological Process: defense response; signal transduction

Leukocyte immunoglobulin-like receptor subfamily A member 3

Also known as Leukocyte immunoglobulin-like receptor subfamily A member 3 (CD85 antigen-like family member E) (Immunoglobulin-like transcript 6) (ILT-6) (Leukocyte immunoglobulin-like receptor 4) (LIR-4) (Monocyte inhibitory receptor HM43/HM31) (CD antigen CD85e).
LILRA3: May act as soluble receptor for class I MHC antigens.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: plasma membrane

Molecular Function: antigen binding; receptor activity

Biological Process: defense response; signal transduction

Leukocyte immunoglobulin-like receptor subfamily A member 4

Also known as Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85 antigen-like family member G) (Immunoglobulin-like transcript 7) (ILT-7) (CD antigen CD85g).
LILRA4: May act as receptor for class I MHC antigens. Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.4

Molecular Function: protein binding

Leukocyte immunoglobulin-like receptor subfamily A member 5

Also known as Leukocyte immunoglobulin-like receptor subfamily A member 5 (CD85 antigen-like family member F) (Immunoglobulin-like transcript 11) (ILT-11) (Leukocyte immunoglobulin-like receptor 9) (LIR-9) (CD antigen CD85f).
LILRA5: May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition. 4 isoforms of the human protein are produced by alternative splicing

Chromosomal Location of Human Ortholog: 19q13.4

Leukocyte immunoglobulin-like receptor subfamily A member 6

Also known as Leukocyte immunoglobulin-like receptor subfamily A member 6 (Immunoglobulin-like transcript 8) (ILT-8) (Leukocyte Ig-like receptor).
LILRA6: May act as receptor for class I MHC antigens. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.4

Leukocyte immunoglobulin-like receptor subfamily B member 1

Also known as Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j).
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Leukocyte immunoglobulin-like receptor subfamily B member 2

Also known as Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d).
LILRB2: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: cell surface; cytoplasm; extracellular space; integral to plasma membrane; membrane; plasma membrane

Molecular Function: cell adhesion molecule binding; inhibitory MHC class I receptor activity; MHC class I protein binding; protein binding; protein phosphatase 1 binding; receptor activity

Biological Process: cell surface receptor linked signal transduction; cell-cell signaling; cellular defense response; Fc receptor mediated inhibitory signaling pathway; heterotypic cell-cell adhesion; immune response; immune response-inhibiting cell surface receptor signaling pathway; negative regulation of antigen processing and presentation; negative regulation of calcium ion transport; negative regulation of immune response; negative regulation of T cell proliferation; positive regulation of regulatory T cell differentiation; positive regulation of T cell proliferation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction; regulation of immune response; signal transduction

Leukocyte immunoglobulin-like receptor subfamily B member 3

Also known as Leukocyte immunoglobulin-like receptor subfamily B member 3 (LIR-3) (Leukocyte immunoglobulin-like receptor 3) (CD85 antigen-like family member A) (Immunoglobulin-like transcript 5) (ILT-5) (Monocyte inhibitory receptor HL9) (CD antigen CD85a).
LILRB3: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B- cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; receptor activity; transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; defense response; negative regulation of osteoclast differentiation

Leukocyte immunoglobulin-like receptor subfamily B member 3A

May act as receptor for class I MHC antigens. Becomes activated upon coligation with immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).

Leukocyte immunoglobulin-like receptor subfamily B member 3B

May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).

Leukocyte immunoglobulin-like receptor subfamily B member 4

Also known as Leukocyte immunoglobulin-like receptor subfamily B member 4 (CD85 antigen-like family member K) (Immunoglobulin-like transcript 3) (ILT-3) (Leukocyte immunoglobulin-like receptor 5) (LIR-5) (Monocyte inhibitory receptor HM18) (CD antigen CD85k).
LILRB4: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Molecular Function: antigen binding; protein binding; receptor activity

Biological Process: negative regulation of osteoclast differentiation; signal transduction

Leukocyte immunoglobulin-like receptor subfamily B member 5

Also known as Leukocyte immunoglobulin-like receptor subfamily B member 5 (CD85 antigen-like family member C) (Leukocyte immunoglobulin-like receptor 8) (LIR-8) (CD antigen CD85c).
LILRB5: May act as receptor for class I MHC antigens. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.4

Molecular Function: transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; defense response

Go back to Proteins Root Name Listing
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000