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Mas-related G-protein coupled receptor

Orphan receptor activated by a subset of RFamide-family neuropeptides such as FLRF-amide and FMRF-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception (By similarity).

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Mas-related G-protein coupled receptor member A1

Also known as Mas-related G-protein coupled receptor member A1 (RF-amide G-protein coupled receptor).
Orphan receptor activated by a subset of RFamide-family neuropeptides such as FLRF-amide and FMRF-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception.

Mas-related G-protein coupled receptor member A2

Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain ().

Mas-related G-protein coupled receptor member A3

Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain (). Activated by the antimalarial drug chloroquine. Mediates chloroquine-induced itch, in a histamine-independent manner.

Mas-related G-protein coupled receptor member A4

Also known as Mas-related G-protein coupled receptor member A4 (RF-amide G-protein coupled receptor).
MRGPRA4: Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Cellular Component: integral to plasma membrane

Molecular Function: neuropeptide receptor activity

Mas-related G-protein coupled receptor member A5

Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain ().

Mas-related G-protein coupled receptor member A8

Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain ().

Mas-related G-protein coupled receptor member B2

MRGPRX1: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in an histamine-independent manner. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: integral to plasma membrane

Molecular Function: G-protein coupled receptor activity

Mas-related G-protein coupled receptor member B3

Mrgprb3: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: Membrane protein, integral

Cellular Component: integral to plasma membrane

Molecular Function: G-protein coupled receptor activity

Mas-related G-protein coupled receptor member D

Also known as Mas-related G-protein coupled receptor member D (Beta-alanine receptor) (G-protein coupled receptor TGR7).
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. The receptor couples with G-protein G(q) and G(i) ().

Mas-related G-protein coupled receptor member E

MRGPRE: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: integral to plasma membrane

Molecular Function: G-protein coupled receptor activity

Mas-related G-protein coupled receptor member F

Also known as Mas-related G-protein coupled receptor member F (Mas-related gene F protein).
MRGPRF: Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: integral to plasma membrane; nuclear membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity

Mas-related G-protein coupled receptor member G

MRGPRG: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: integral to plasma membrane

Molecular Function: G-protein coupled receptor activity

Mas-related G-protein coupled receptor member X1

Also known as Mas-related G-protein coupled receptor member X1 (Mas-related G-protein coupled receptor member C11) (Sensory neuron-specific G-protein coupled receptor 1).
MRGPRX4: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: integral to plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: chemosensory behavior; hemopoietic progenitor cell differentiation

Mas-related G-protein coupled receptor member X2

Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction.

Mas-related G-protein coupled receptor member X3

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins ().

Mas-related G-protein coupled receptor member X4

Also known as Mas-related G-protein coupled receptor member X4 (Sensory neuron-specific G-protein coupled receptor 5/6).
MRGPRX4: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: integral to plasma membrane

Molecular Function: G-protein coupled receptor activity

Mas-related G-protein coupled receptor MRG

Also known as Mas-related G-protein coupled receptor MRG (MAS-R) (MAS1-like).
MAS1L: Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: cytoplasm; integral to plasma membrane; nucleoplasm; plasma membrane

Molecular Function: G-protein coupled receptor activity

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