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Meiotic recombination protein

Required for meiotic recombination, synaptonemal complex formation and cell cycle progression.

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Meiotic recombination protein DLH1

Also known as Meiotic recombination protein DLH1 (DMC1 homolog).
Required for meiotic recombination, synaptonemal complex formation and cell cycle progression.

Meiotic recombination protein dmc1

Required for meiotic recombination and cell cycle progression. Binds to single and double-stranded DNA, in the presence of magnesium, and exhibits DNA-dependent ATPase activity. Promotes DNA strand annealing and strand exchange via DNA recombinase activity and forms helical and stacked ring nucleoprotein filaments.

Meiotic recombination protein DMC1/LIM15 homolog

DMC1: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Belongs to the RecA family. DMC1 subfamily.

Protein type: Cell cycle regulation; Cell development/differentiation; DNA repair, damage

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: chromosome; nucleoplasm; nucleus

Molecular Function: DNA binding; DNA-dependent ATPase activity; double-stranded DNA binding; endodeoxyribonuclease activity; four-way junction DNA binding; protein binding; recombinase activity; single-stranded DNA binding

Biological Process: DNA recombinase assembly; female gamete generation; meiosis; mitotic recombination; response to ionizing radiation; spermatogenesis; strand invasion

Meiotic recombination protein rdh54

Also known as Meiotic recombination protein rdh54 (ATP-dependent helicase rdh54) (Meiotically up-regulated gene 34 protein) (RAD54 protein homolog 2).
Acts with rhp54 to repair meiotic double strand breaks via homologous recombination. Involved in meiotic DNA recombination.

Meiotic recombination protein REC102

Required for formation of the SPO11-mediated double-strand breaks (DSBs) that initiate meiotic recombination. May mediate the interaction between SPO11 subunits during meiosis. Also needed for homolog chromosome pairing, synaptonemal complex formation, and for the proper timing of the first meiotic division. Not required for mitosis and mitotic DNA repair mechanisms.

Meiotic recombination protein rec12

Also known as Meiotic recombination protein rec12 (SPO11 protein homolog).
Required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination (PubMed:10882124). Required for crossover recombination and chiasmatic segregation of chromosomes during meiosis I. Also involved in the faithful equational segregation of chromosomes during meiosis II (PubMed:12437782, PubMed:16303567).

Meiotic recombination protein rec15

Required during the early stages of meiosis for meiotic recombination. Involved in chromosome segregation where it is required for seperation of sister chromatids in all three chromosomes.

Meiotic recombination protein rec6

Required for formation of the rec12-mediated double-strand breaks (DSBs) that initiate meiotic recombination (PubMed:10882124). May be involved primarily in the early steps of meiotic recombination (Probable).

Meiotic recombination protein rec8

Also known as Meiotic recombination protein rec8 (Cohesin rec8).
Involved primarily in the early steps of meiotic recombination. Required to ensure reductional chromosome segregation.

Meiotic recombination protein rec-8

Also known as Meiotic recombination protein rec-8 (Cohesin rec-8).
Plays a role in meiotic chromosome cohesion and segregation (PubMed:11390355, PubMed:25171895). Necessary for sister chromatid co-orientation and sister chromatid cohension until meiosis II (PubMed:19574299). May also be required for repair of programmed meiotic double stranded breaks (PubMed:11390355).

Meiotic recombination protein REC8 homolog

Also known as Meiotic recombination protein REC8 homolog (Cohesin Rec8p).
REC8: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II. Belongs to the rad21 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q11.2-q12

Cellular Component: nucleus

Molecular Function: chromatin binding

Biological Process: double-strand break repair; meiosis; meiotic recombination; sister chromatid cohesion; spermatogenesis

Meiotic recombination protein SPO11

SPO11: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. Belongs to the TOP6A family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA); Cell cycle regulation; Cell development/differentiation

Cellular Component: chromosome, telomeric region; nuclear chromosome

Molecular Function: DNA binding; DNA topoisomerase (ATP-hydrolyzing) activity; endodeoxyribonuclease activity, producing 3'-phosphomonoesters

Biological Process: leptotene; male meiosis I; meiotic DNA double-strand break formation; meiotic DNA double-strand break processing; meiotic recombination; oogenesis; ovarian follicle development; spermatid development; synapsis; synaptonemal complex assembly; telomere clustering

Meiotic recombination protein SPO11-1

Also known as Meiotic recombination protein SPO11-1 (AtSPO11-1).
Encodes AtSPO11-1, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. AtSPO11-1 accumulates in foci in early G2. At 1 h post-S phase, no foci are observed, but by 3 h a majority (80%) of meiocytes at this time point contain >50 foci. However, by 5 h, AtSPO11-1 foci are no longer detectable. This suggests that the protein undergoes a rapid cycle of accumulation and disappearance in meiocytes over a period of between 1 and 5 h post-S phase.

Meiotic recombination protein SPO11-2

Also known as Meiotic recombination protein SPO11-2 (AtSPO11-2).
Encodes AtSPO11-2, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. Plants homozygous for atspo11-2 exhibit a severe sterility phenotype. Both male and female meiosis are severely disrupted in the atspo11-2 mutant, and this is associated with severe defects in synapsis during the first meiotic division and reduced meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. Required for double-strand break induction.

Meiotic recombination protein W68

Also known as Meiotic recombination protein W68 (SPO11 protein homolog).
Required for meiotic recombination (PubMed:9744869). Together with mei-P22, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination ().

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