Meiotic recombination protein
Required for meiotic recombination, synaptonemal complex formation and cell cycle progression.
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Meiotic recombination protein DLH1
Also known as Meiotic recombination protein DLH1 (DMC1 homolog).
Required for meiotic recombination, synaptonemal complex formation and cell cycle progression.
Required for meiotic recombination, synaptonemal complex formation and cell cycle progression.
Meiotic recombination protein dmc1
Required for meiotic recombination and cell cycle progression. Binds to single and double-stranded DNA, in the presence of magnesium, and exhibits DNA-dependent ATPase activity. Promotes DNA strand annealing and strand exchange via DNA recombinase activity and forms helical and stacked ring nucleoprotein filaments.
Meiotic recombination protein DMC1/LIM15 homolog
DMC1: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Belongs to the RecA family. DMC1 subfamily.
Protein type: Cell cycle regulation; Cell development/differentiation; DNA repair, damage
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: chromosome; nucleoplasm; nucleus
Molecular Function: DNA binding; DNA-dependent ATPase activity; double-stranded DNA binding; endodeoxyribonuclease activity; four-way junction DNA binding; protein binding; recombinase activity; single-stranded DNA binding
Biological Process: DNA recombinase assembly; female gamete generation; meiosis; mitotic recombination; response to ionizing radiation; spermatogenesis; strand invasion
Protein type: Cell cycle regulation; Cell development/differentiation; DNA repair, damage
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: chromosome; nucleoplasm; nucleus
Molecular Function: DNA binding; DNA-dependent ATPase activity; double-stranded DNA binding; endodeoxyribonuclease activity; four-way junction DNA binding; protein binding; recombinase activity; single-stranded DNA binding
Biological Process: DNA recombinase assembly; female gamete generation; meiosis; mitotic recombination; response to ionizing radiation; spermatogenesis; strand invasion
Meiotic recombination protein P22
Required for formation of the mei-W68-mediated double-strand breaks (DSBs) that initiate meiotic recombination.
Meiotic recombination protein rdh54
Also known as Meiotic recombination protein rdh54 (ATP-dependent helicase rdh54) (Meiotically up-regulated gene 34 protein) (RAD54 protein homolog 2).
Acts with rhp54 to repair meiotic double strand breaks via homologous recombination. Involved in meiotic DNA recombination.
Acts with rhp54 to repair meiotic double strand breaks via homologous recombination. Involved in meiotic DNA recombination.
Meiotic recombination protein rec10
Involved primarily in the early steps of meiotic recombination localized to chromosome III.
Meiotic recombination protein REC102
Required for formation of the SPO11-mediated double-strand breaks (DSBs) that initiate meiotic recombination. May mediate the interaction between SPO11 subunits during meiosis. Also needed for homolog chromosome pairing, synaptonemal complex formation, and for the proper timing of the first meiotic division. Not required for mitosis and mitotic DNA repair mechanisms.
Meiotic recombination protein REC104
Potential transcriptional regulator that is required to activate expression of a number of early meiotic genes including HOP1.
Meiotic recombination protein REC114
Required for meiotic recombination events; not required for mitosis.
Meiotic recombination protein rec12
Also known as Meiotic recombination protein rec12 (SPO11 protein homolog).
Required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination (PubMed:10882124). Required for crossover recombination and chiasmatic segregation of chromosomes during meiosis I. Also involved in the faithful equational segregation of chromosomes during meiosis II (PubMed:12437782, PubMed:16303567).
Required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination (PubMed:10882124). Required for crossover recombination and chiasmatic segregation of chromosomes during meiosis I. Also involved in the faithful equational segregation of chromosomes during meiosis II (PubMed:12437782, PubMed:16303567).
Meiotic recombination protein rec14
Required for formation of the rec12-mediated double-strand breaks (DSBs) that initiate meiotic recombination.
Meiotic recombination protein rec15
Required during the early stages of meiosis for meiotic recombination. Involved in chromosome segregation where it is required for seperation of sister chromatids in all three chromosomes.
Meiotic recombination protein rec24
Also known as Meiotic recombination protein rec24 (Meiotically up-regulated gene 6 protein).
Required for correct meiotic chromosome segregation and recombination.
Required for correct meiotic chromosome segregation and recombination.
Meiotic recombination protein rec25
Also known as Meiotic recombination protein rec25 (Meiotically up-regulated gene 19 protein).
Required for correct meiotic chromosome segregation and recombination.
Required for correct meiotic chromosome segregation and recombination.
Meiotic recombination protein rec27
Also known as Meiotic recombination protein rec27 (Meiotically up-regulated gene 41 protein).
Required for correct meiotic chromosome segregation and recombination.
Required for correct meiotic chromosome segregation and recombination.
Meiotic recombination protein rec6
Required for formation of the rec12-mediated double-strand breaks (DSBs) that initiate meiotic recombination (PubMed:10882124). May be involved primarily in the early steps of meiotic recombination (Probable).
Meiotic recombination protein rec7
May be involved primarily in the early steps of meiotic recombination.
Meiotic recombination protein rec8
Also known as Meiotic recombination protein rec8 (Cohesin rec8).
Involved primarily in the early steps of meiotic recombination. Required to ensure reductional chromosome segregation.
Involved primarily in the early steps of meiotic recombination. Required to ensure reductional chromosome segregation.
Meiotic recombination protein rec-8
Also known as Meiotic recombination protein rec-8 (Cohesin rec-8).
Plays a role in meiotic chromosome cohesion and segregation (PubMed:11390355, PubMed:25171895). Necessary for sister chromatid co-orientation and sister chromatid cohension until meiosis II (PubMed:19574299). May also be required for repair of programmed meiotic double stranded breaks (PubMed:11390355).
Plays a role in meiotic chromosome cohesion and segregation (PubMed:11390355, PubMed:25171895). Necessary for sister chromatid co-orientation and sister chromatid cohension until meiosis II (PubMed:19574299). May also be required for repair of programmed meiotic double stranded breaks (PubMed:11390355).
Meiotic recombination protein REC8 homolog
Also known as Meiotic recombination protein REC8 homolog (Cohesin Rec8p).
REC8: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II. Belongs to the rad21 family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 14q11.2-q12
Cellular Component: nucleus
Molecular Function: chromatin binding
Biological Process: double-strand break repair; meiosis; meiotic recombination; sister chromatid cohesion; spermatogenesis
REC8: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II. Belongs to the rad21 family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 14q11.2-q12
Cellular Component: nucleus
Molecular Function: chromatin binding
Biological Process: double-strand break repair; meiosis; meiotic recombination; sister chromatid cohesion; spermatogenesis
Meiotic recombination protein spo-11
Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination.
Meiotic recombination protein SPO11
SPO11: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. Belongs to the TOP6A family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cancer Testis Antigen (CTA); Cell cycle regulation; Cell development/differentiation
Cellular Component: chromosome, telomeric region; nuclear chromosome
Molecular Function: DNA binding; DNA topoisomerase (ATP-hydrolyzing) activity; endodeoxyribonuclease activity, producing 3'-phosphomonoesters
Biological Process: leptotene; male meiosis I; meiotic DNA double-strand break formation; meiotic DNA double-strand break processing; meiotic recombination; oogenesis; ovarian follicle development; spermatid development; synapsis; synaptonemal complex assembly; telomere clustering
Protein type: Cancer Testis Antigen (CTA); Cell cycle regulation; Cell development/differentiation
Cellular Component: chromosome, telomeric region; nuclear chromosome
Molecular Function: DNA binding; DNA topoisomerase (ATP-hydrolyzing) activity; endodeoxyribonuclease activity, producing 3'-phosphomonoesters
Biological Process: leptotene; male meiosis I; meiotic DNA double-strand break formation; meiotic DNA double-strand break processing; meiotic recombination; oogenesis; ovarian follicle development; spermatid development; synapsis; synaptonemal complex assembly; telomere clustering
Meiotic recombination protein SPO11-1
Also known as Meiotic recombination protein SPO11-1 (AtSPO11-1).
Encodes AtSPO11-1, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. AtSPO11-1 accumulates in foci in early G2. At 1 h post-S phase, no foci are observed, but by 3 h a majority (80%) of meiocytes at this time point contain >50 foci. However, by 5 h, AtSPO11-1 foci are no longer detectable. This suggests that the protein undergoes a rapid cycle of accumulation and disappearance in meiocytes over a period of between 1 and 5 h post-S phase.
Encodes AtSPO11-1, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. AtSPO11-1 accumulates in foci in early G2. At 1 h post-S phase, no foci are observed, but by 3 h a majority (80%) of meiocytes at this time point contain >50 foci. However, by 5 h, AtSPO11-1 foci are no longer detectable. This suggests that the protein undergoes a rapid cycle of accumulation and disappearance in meiocytes over a period of between 1 and 5 h post-S phase.
Meiotic recombination protein SPO11-2
Also known as Meiotic recombination protein SPO11-2 (AtSPO11-2).
Encodes AtSPO11-2, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. Plants homozygous for atspo11-2 exhibit a severe sterility phenotype. Both male and female meiosis are severely disrupted in the atspo11-2 mutant, and this is associated with severe defects in synapsis during the first meiotic division and reduced meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. Required for double-strand break induction.
Encodes AtSPO11-2, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. Plants homozygous for atspo11-2 exhibit a severe sterility phenotype. Both male and female meiosis are severely disrupted in the atspo11-2 mutant, and this is associated with severe defects in synapsis during the first meiotic division and reduced meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. Required for double-strand break induction.
Meiotic recombination protein SPO11-4
Also known as Meiotic recombination protein SPO11-4 (OsSPO11-4) (OsSPO11D).
Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. Possesses double-stranded DNA cleavage activity in vitro.
Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. Possesses double-stranded DNA cleavage activity in vitro.
Meiotic recombination protein W68
Also known as Meiotic recombination protein W68 (SPO11 protein homolog).
Required for meiotic recombination (PubMed:9744869). Together with mei-P22, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination ().
Required for meiotic recombination (PubMed:9744869). Together with mei-P22, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination ().
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